Mike Aoun
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Explore the profile of Mike Aoun including associated specialties, affiliations and a list of published articles.
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11
Citations
60
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Recent Articles
1.
Ueda Y, Kiyonaka S, Selfors L, Inoue K, Harada H, Doura T, et al.
Nat Cell Biol
. 2025 Feb;
27(3):530-543.
PMID: 39984655
Intratumour heterogeneity represents the hierarchical integration of genetic, phenotypic and microenvironmental heterogeneity. Although single-cell sequencing has clarified genetic and phenotypic variability, the heterogeneity of nongenetic, microenvironmental factors remains elusive. Here,...
2.
Tricomi J, Aoun M, Xu B, Holmdahl R, Richichi B
Chembiochem
. 2024 Mar;
25(9):e202400026.
PMID: 38506247
In this work, we have discovered that the Gal-α-(1→3)-Gal-β-(1→3)-GlcNAc trisaccharide, a fragment of the B antigen Type-1, is a new ligand of two C-type lectin receptors (CLRs) i. e. DCAR...
3.
He Y, Aoun M, Xu Z, Holmdahl R
Ann Rheum Dis
. 2024 Feb;
83(5):550-555.
PMID: 38413169
A hallmark of rheumatoid arthritis (RA) is the increased levels of autoantibodies preceding the onset and contributing to the classification of the disease. These autoantibodies, mainly anti-citrullinated protein antibody (ACPA)...
4.
Aoun M, Coelho A, Kramer A, Saxena A, Sabatier P, Beusch C, et al.
J Exp Med
. 2023 Oct;
220(11).
PMID: 37788218
No abstract available.
5.
Aoun M, Coelho A, Kramer A, Saxena A, Sabatier P, Beusch C, et al.
J Exp Med
. 2023 Sep;
220(11).
PMID: 37695523
B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using...
6.
Zhang J, Koolmeister C, Han J, Filograna R, Hanke L, Adori M, et al.
JCI Insight
. 2023 Sep;
8(17).
PMID: 37681412
Pathogenic mutations in mitochondrial (mt) tRNA genes that compromise oxidative phosphorylation (OXPHOS) exhibit heteroplasmy and cause a range of multisyndromic conditions. Although mitochondrial disease patients are known to suffer from...
7.
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
He Y, Ge C, Moreno-Giro A, Xu B, Beusch C, Sandor K, et al.
Nat Commun
. 2023 Feb;
14(1):691.
PMID: 36754962
Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we have expressed monoclonal ACPAs...
8.
Aoun M, Cai X, Xu B, Lahore G, Bonner M, He Y, et al.
Antioxidants (Basel)
. 2022 Jan;
11(1).
PMID: 35052516
Animal models for complex diseases are needed to position and analyze the function of interacting genes. Previous positional cloning identified Ncf1 and Clec4b to be major regulators of arthritis models...
9.
Sabatier P, Beusch C, Saei A, Aoun M, Moruzzi N, Coelho A, et al.
Nat Commun
. 2021 Nov;
12(1):6558.
PMID: 34772928
Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. To systematically study such transitions,...
10.
Lahore G, Forster M, Johannesson M, Sabatier P, Lonnblom E, Aoun M, et al.
Nat Commun
. 2021 Sep;
12(1):5565.
PMID: 34552089
Complex autoimmune diseases are sexually dimorphic. An interplay between predisposing genetics and sex-related factors probably controls the sex discrepancy in the immune response, but the underlying mechanisms are unclear. Here...