Mike A Clark
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Explore the profile of Mike A Clark including associated specialties, affiliations and a list of published articles.
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12
Citations
646
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Recent Articles
1.
Thamm D, Kurzman I, Clark M, Ehrhart 3rd E, Kraft S, Gustafson D, et al.
Clin Cancer Res
. 2010 Feb;
16(5):1498-508.
PMID: 20160058
Purpose: Tumor necrosis factor-alpha (TNF) is a cytokine with potent antitumor activity; however, toxicity and short half-life have limited its utility. Polyethylene glycol (PEG) conjugation of biotherapeutics can decrease immunogenicity...
2.
Izzo F, Montella M, Orlando A, Nasti G, Beneduce G, Castello G, et al.
J Gastroenterol Hepatol
. 2007 Jan;
22(1):86-91.
PMID: 17201887
Background: The arginine-degrading enzyme, arginine deiminase conjugated to polyethylene glycol (ADI-SS PEG 20,000 mw), reduces extracellular arginine, has minimal toxicity, decreases tumor burden and improves liver function in patients with...
3.
Ascierto P, Scala S, Castello G, Daponte A, Simeone E, Ottaiano A, et al.
J Clin Oncol
. 2005 Oct;
23(30):7660-8.
PMID: 16234528
Purpose: Individuals with metastatic melanoma have a poor prognosis. Many human melanomas are auxotrophic for arginine, and arginine is not an essential amino acid in humans. We hypothesized that this...
4.
Izzo F, Marra P, Beneduce G, Castello G, Vallone P, De Rosa V, et al.
J Clin Oncol
. 2004 May;
22(10):1815-22.
PMID: 15143074
Purpose: Recently, we reported that a large number of human hepatocellular cancer (HCC) cell lines were auxotrophic for arginine. Here we report the results obtained with the amino acid-degrading enzyme...
5.
Bomalaski J, Clark M
Curr Rheumatol Rep
. 2004 May;
6(3):240-7.
PMID: 15134605
Although allopurinol has been available for approximately 50 years, hyperuricemia and its sequelae are not only prevalent, but the incidence and costs associated with this disorder continue to increase. However,...
6.
Dillon B, Prieto V, Curley S, Ensor C, Holtsberg F, Bomalaski J, et al.
Cancer
. 2004 Feb;
100(4):826-33.
PMID: 14770441
Background: Argininosuccinate synthetase (ASS) was the first of two enzymes to convert citrulline to arginine. This pathway allowed cells to synthesize arginine from citrulline, making this amino acid nonessential for...
7.
Curley S, Bomalaski J, Ensor C, Holtsberg F, Clark M
Hepatogastroenterology
. 2003 Oct;
50(53):1214-6.
PMID: 14571701
We report the first pharmacokinetic and clinical response data from a patient with unresectable hepatocellular cancer treated with a new drug, ADI PEG20,000 mw (arginine deiminase-polyethylene glycol 20,000 molecular weight)....
8.
Ensor C, Holtsberg F, Bomalaski J, Clark M
Cancer Res
. 2002 Oct;
62(19):5443-50.
PMID: 12359751
Some murine melanomas and hepatocellular carcinomas (HCCs) have been shown to be auxotrophic for arginine. Arginine deiminase (ADI; EC 3.5.3.6.), an arginine-degrading enzyme isolated from Mycoplasma, can inhibit growth of...
9.
Bomalaski J, Holtsberg F, Ensor C, Clark M
J Rheumatol
. 2002 Sep;
29(9):1942-9.
PMID: 12233890
Objective: Humans have a non-sense codon inserted into the 5 prime end of the open reading frame of urate oxidase, and thus express an enzymatically inactive fragment of this enzyme;...
10.
Dillon B, Holtsberg F, Ensor C, Bomalaski J, Clark M
Med Sci Monit
. 2002 Jul;
8(7):BR248-53.
PMID: 12118186
Background: Nitric oxide (NO) is a biomediator believed to be synthesized primarily from extracellular arginine. Various methodologies have been used to inhibit NO synthesis so as to elucidate its physiological...