Mikako Harata
Overview
Explore the profile of Mikako Harata including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
82
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Recent Articles
1.
Arriola-Montenegro J, Mutirangura P, Akram H, Tsangaris A, Koukousaki D, Tschida M, et al.
Heart Fail Rev
. 2024 Oct;
PMID: 39436486
Heart failure remains one of the leading causes of mortality and hospitalizations in the US that not only impacts quality of life but also poses a significant public health burden....
2.
Mastoor Y, Harata M, Silva K, Liu C, Combs C, Roman B, et al.
J Mol Cell Cardiol Plus
. 2024 Jun;
8.
PMID: 38854449
An increase in mitochondrial calcium via the mitochondrial calcium uniporter (MCU) has been implicated in initiating cell death in the heart during ischemia-reperfusion (I/R) injury. Measurement of calcium during I/R...
3.
Robichaux D, Harata M, Murphy E, Karch J
J Mol Cell Cardiol
. 2022 Nov;
174:47-55.
PMID: 36410526
Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is triggered by...
4.
Sebag S, Zhang Z, Qian Q, Li M, Zhu Z, Harata M, et al.
Cell Rep
. 2021 Nov;
37(7):110003.
PMID: 34788615
Brown adipose tissue (BAT) thermogenic activity is tightly regulated by cellular redox status, but the underlying molecular mechanisms are incompletely understood. Protein S-nitrosylation, the nitric-oxide-mediated cysteine thiol protein modification, plays...
5.
Mishra A, Liu S, Promes J, Harata M, Sivitz W, Fink B, et al.
JCI Insight
. 2021 Mar;
6(9).
PMID: 33784258
Perilipin 2 (PLIN2) is a lipid droplet (LD) protein in β cells that increases under nutritional stress. Downregulation of PLIN2 is often sufficient to reduce LD accumulation. To determine whether...
6.
Liu S, Promes J, Harata M, Mishra A, Stephens S, Taylor E, et al.
Diabetes
. 2020 Apr;
69(6):1178-1192.
PMID: 32312867
Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse β-cells, LDs are prominent in human β-cells. However, the regulation of LD mobilization...
7.
Liu S, Promes J, Harata M, Mishra A, Stephens S, Taylor E, et al.
Diabetes
. 2020 Apr;
PMID: 32234723
Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse beta cells, LDs are prominent in human beta cells, however, the regulation of...
8.
Liu S, Harata M, Promes J, Burand A, Ankrum J, Imai Y
J Vis Exp
. 2019 Jun;
(147).
PMID: 31157773
Various genetic tools are available to modulate genes in pancreatic islets of rodents to dissect function of islet genes for diabetes research. However, the data obtained from rodent islets are...
9.
Harata M, Liu S, Promes J, Burand A, Ankrum J, Imai Y
Physiol Rep
. 2018 Oct;
6(20):e13907.
PMID: 30370689
Rodent islets are widely used to study the pathophysiology of beta cells and islet function, however, structural and functional differences exist between human and rodent islets, highlighting the need for...
10.
Yamawaki T, Fujihara Y, Harata M, Takato T, Hikita A, Hoshi K
Regen Ther
. 2018 Oct;
8:1-8.
PMID: 30271859
Restoration of damaged cartilage tissue has been deemed futile with current treatments. Although there have been many studies on cartilage regeneration thus far, there is no report that chondrocytes were...