Mikael V Garabedian
Overview
Explore the profile of Mikael V Garabedian including associated specialties, affiliations and a list of published articles.
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13
Citations
176
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Recent Articles
1.
Welles R, Sojitra K, Garabedian M, Xia B, Wang W, Guan M, et al.
Nat Chem
. 2024 Feb;
16(7):1062-1072.
PMID: 38316988
Cells harbour numerous mesoscale membraneless compartments that house specific biochemical processes and perform distinct cellular functions. These protein- and RNA-rich bodies are thought to form through multivalent interactions among proteins...
2.
Welles R, Sojitra K, Garabedian M, Xia B, Wang W, Guan M, et al.
bioRxiv
. 2023 Mar;
PMID: 36945618
Cells harbor numerous mesoscale membraneless compartments that house specific biochemical processes and perform distinct cellular functions. These protein and RNA-rich bodies are thought to form through multivalent interactions among proteins...
3.
Garabedian M, Su Z, Dabdoub J, Tong M, Deiters A, Hammer D, et al.
Biochemistry
. 2022 Aug;
61(22):2470-2481.
PMID: 35918061
Many proteins harboring low complexity or intrinsically disordered sequences (IDRs) are capable of undergoing liquid-liquid phase separation to form mesoscale condensates that function as biochemical niches with the ability to...
4.
Guan M, Garabedian M, Leutenegger M, Schuster B, Good M, Hammer D
Biochemistry
. 2021 Oct;
60(42):3137-3151.
PMID: 34648259
Eukaryotic cells partition enzymes and other cellular components into distinct subcellular compartments to generate specialized biochemical niches. A subclass of these compartments form in the absence of lipid membranes, via...
5.
Garabedian M, Wang W, Dabdoub J, Tong M, Caldwell R, Benman W, et al.
Nat Chem Biol
. 2021 Aug;
17(9):998-1007.
PMID: 34341589
Subcellular compartmentalization of macromolecules increases flux and prevents inhibitory interactions to control biochemical reactions. Inspired by this functionality, we sought to build designer compartments that function as hubs to regulate...
6.
7.
Garabedian M, Wirshing A, Vakhrusheva A, Turegun B, Sokolova O, Goode B
Mol Biol Cell
. 2020 Jun;
31(18):1988-2001.
PMID: 32579428
Cellular actin arrays are often highly organized, with characteristic patterns critical to their in vivo functions, yet the mechanisms for establishing these higher order geometries remain poorly understood. In formin-polymerized...
8.
Pollard L, Garabedian M, Alioto S, Shekhar S, Goode B
Mol Biol Cell
. 2020 Jan;
31(5):335-347.
PMID: 31913750
A major goal of synthetic biology is to define the minimal cellular machinery required to assemble a biological structure in its simplest form. Here, we focused on actin cables, which...
9.
Garabedian M, Stanishneva-Konovalova T, Lou C, Rands T, Pollard L, Sokolova O, et al.
J Cell Biol
. 2018 Aug;
217(10):3512-3530.
PMID: 30076201
Formins are essential actin assembly factors whose activities are controlled by a diverse array of binding partners. Until now, most formin ligands have been studied on an individual basis, leaving...
10.
Botchkarev Jr V, Garabedian M, Lemos B, Paulissen E, Haber J
Mol Biol Cell
. 2017 Feb;
28(8):1011-1020.
PMID: 28228549
The budding yeast Polo-like kinase Cdc5 is a key regulator of many mitotic events. Cdc5 coordinates its functions spatially and temporally by changing its localization during the cell cycle: Cdc5...