Mihaly Kovacs
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Explore the profile of Mihaly Kovacs including associated specialties, affiliations and a list of published articles.
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Articles
66
Citations
2065
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Recent Articles
1.
Sipos S, Balazs B, Gati T, Csekei M, Kovaacs M, Kovacs M, et al.
ChemMedChem
. 2025 Feb;
:e202400970.
PMID: 39895364
Atropisomersm is an emerging feature in recent drug candidates due to the increasing complexity of the targeted protein surfaces. The developability of the drug candidates requires that their atropisomer interconversion...
2.
Harami G, Palinkas J, Kovacs Z, Jezso B, Tarnok K, Harami-Papp H, et al.
iScience
. 2024 Sep;
27(9):110788.
PMID: 39286502
Human single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) plays central roles in DNA repair. Here, we show that purified hSSB1 undergoes redox-dependent liquid-liquid phase separation (LLPS) in the presence of single-stranded...
3.
Hegedus L, Toth A, Harami G, Palinkas J, Karatayeva N, Sajben-Nagy E, et al.
Sci Rep
. 2024 Jul;
14(1):15740.
PMID: 38977862
Genome replication is frequently impeded by highly stable DNA secondary structures, including G-quadruplex (G4) DNA, that can hinder the progression of the replication fork. Human WRNIP1 (Werner helicase Interacting Protein...
4.
Kovacs Z, Harami G, Palinkas J, Kuljanishvili N, Hegedus J, Harami-Papp H, et al.
Protein Sci
. 2024 Mar;
33(4):e4959.
PMID: 38511671
Single-stranded DNA binding proteins (SSBs) are ubiquitous across all domains of life and play essential roles via stabilizing and protecting single-stranded (ss) DNA as well as organizing multiprotein complexes during...
5.
Annus T, Muller D, Jezso B, Ullaga G, Nemeth B, Harami G, et al.
Cell Death Dis
. 2022 Apr;
13(4):363.
PMID: 35436990
RecQ helicases-also known as the "guardians of the genome"-play crucial roles in genome integrity maintenance through their involvement in various DNA metabolic pathways. Aside from being conserved from bacteria to...
6.
Harami G, Palinkas J, Seol Y, Kovacs Z, Gyimesi M, Harami-Papp H, et al.
Nat Commun
. 2022 Feb;
13(1):654.
PMID: 35115525
Homologous recombination (HR) is a ubiquitous and efficient process that serves the repair of severe forms of DNA damage and the generation of genetic diversity during meiosis. HR can proceed...
7.
Szeltner Z, Poti A, Harami G, Kovacs M, Szuts D
FEBS Open Bio
. 2021 Jan;
11(4):1054-1075.
PMID: 33512058
DNA damage removal by nucleotide excision repair (NER) and replicative bypass via translesion synthesis (TLS) and template switch (TSw) are important in ensuring genome stability. In this study, we tested...
8.
Gyimesi M, Rauscher A, Suthar S, Hamow K, Oravecz K, Lorincz I, et al.
J Pharmacol Exp Ther
. 2021 Jan;
376(3):358-373.
PMID: 33468641
Blebbistatin, -nitroblebbistatin (NBleb), and -aminoblebbistatin (AmBleb) are highly useful tool compounds as they selectively inhibit the ATPase activity of myosin-2 family proteins. Despite the medical importance of the myosin-2 family...
9.
Gyimesi M, Horvath A, Turos D, Suthar S, Penzes M, Kurdi C, et al.
Cell
. 2020 Oct;
183(2):335-346.e13.
PMID: 33035452
Muscle spasticity after nervous system injuries and painful low back spasm affect more than 10% of global population. Current medications are of limited efficacy and cause neurological and cardiovascular side...
10.
Harami G, Kovacs Z, Pancsa R, Palinkas J, Barath V, Tarnok K, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(42):26206-26217.
PMID: 33020264
Bacterial single-stranded (ss)DNA-binding proteins (SSB) are essential for the replication and maintenance of the genome. SSBs share a conserved ssDNA-binding domain, a less conserved intrinsically disordered linker (IDL), and a...