Miguel Lafarga
Overview
Explore the profile of Miguel Lafarga including associated specialties, affiliations and a list of published articles.
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Articles
97
Citations
1901
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Recent Articles
1.
Berciano M, Gatius A, Puente-Bedia A, Rufino-Gomez A, Tarabal O, Rodriguez-Rey J, et al.
Int J Mol Sci
. 2024 Nov;
25(22).
PMID: 39596480
Spinal muscular atrophy (SMA) is caused by a deficiency of the ubiquitously expressed survival motor neuron (SMN) protein. The main pathological hallmark of SMA is the degeneration of lower motor...
2.
Frances R, Mata-Garrido J, Lafarga M, Hurle M, Tramullas M
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39518978
Neuropathic pain is a prevalent and debilitating chronic syndrome that is often resistant to treatment. It frequently arises as a consequence of damage to first-order nociceptive neurons in the lumbar...
3.
Murga M, Lopez-Pernas G, Soliva R, Fueyo-Marcos E, Amor C, Faustino I, et al.
Cell Death Dis
. 2024 Sep;
15(9):694.
PMID: 39341827
SETD8 is a methyltransferase that is overexpressed in several cancers, which monomethylates H4K20 as well as other non-histone targets such as PCNA or p53. We here report novel SETD8 inhibitors,...
4.
Bodas C, Felipe I, Chanez B, Lafarga M, Lopez de Maturana E, Martinez-de-Villarreal J, et al.
bioRxiv
. 2024 Aug;
PMID: 39211105
Objective: Genome wide association studies have identified an exon 6 deletion variant that associates with increased risk of pancreatic cancer. To acquire evidence on its causal role, we developed a...
5.
Lopez-Polo V, Maus M, Zacharioudakis E, Lafarga M, Stephan-Otto Attolini C, Marques F, et al.
Nat Commun
. 2024 Aug;
15(1):7378.
PMID: 39191740
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the...
6.
Porebski B, Christ W, Corman A, Haraldsson M, Barz M, Lidemalm L, et al.
Mol Ther
. 2024 Jul;
32(9):3012-3024.
PMID: 38956870
Several viruses hijack various forms of endocytosis in order to infect host cells. Here, we report the discovery of a molecule with antiviral properties that we named virapinib, which limits...
7.
Bustamante-Madrid P, Barbachano A, Albandea-Rodriguez D, Rodriguez-Cobos J, Rodriguez-Salas N, Prieto I, et al.
Cell Death Dis
. 2024 Apr;
15(4):301.
PMID: 38684650
Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and cancer. Organoid cultures provide an unique tool to address these questions but...
8.
Maus M, Lopez-Polo V, Mateo L, Lafarga M, Aguilera M, De Lama E, et al.
Nat Metab
. 2023 Dec;
5(12):2111-2130.
PMID: 38097808
Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases...
9.
Sanchez-Aguilera A, Masmudi-Martin M, Navas-Olive A, Baena P, Hernandez-Oliver C, Priego N, et al.
Cancer Cell
. 2023 Aug;
41(9):1637-1649.e11.
PMID: 37652007
A high percentage of patients with brain metastases frequently develop neurocognitive symptoms; however, understanding how brain metastasis co-opts the function of neuronal circuits beyond a tumor mass effect remains unknown....
10.
Puente-Bedia A, Berciano M, Martinez-Cue C, Lafarga M, Rueda N
Antioxidants (Basel)
. 2022 Dec;
11(12).
PMID: 36552646
Oxidative stress (OS) is one of the neuropathological mechanisms responsible for the deficits in cognition and neuronal function in Down syndrome (DS). The Ts65Dn (TS) mouse replicates multiple DS phenotypes...