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Mieke C Louwe

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Articles 16
Citations 244
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Recent Articles
1.
Louwe M, Gialeli C, Michelsen A, Holm S, Edsfeldt A, Skagen K, et al.
J Am Heart Assoc . 2025 Jan; 14(3):e038316. PMID: 39868499
Background: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related...
2.
Lauritzen K, Yang K, Frisk M, Louwe M, Olsen M, Ziegler M, et al.
Front Immunol . 2025 Jan; 15():1497984. PMID: 39840045
Introduction: CD38, a regulator of intracellular calcium signalling, is highly expressed in immune cells. Mice lacking CD38 are very susceptible to acute bacterial infections, implicating CD38 in innate immune responses....
3.
Olsen M, Louwe M, Yang K, Ogaard J, Dahl T, Gregersen I, et al.
Biochem Biophys Res Commun . 2024 Sep; 733:150706. PMID: 39305571
Specialized pro-resolving mediators (SPMs) are key effectors of resolution of inflammation. This is highly relevant for cardiac and vessel remodeling, where the net inflammatory response contributes to determine disease outcome....
4.
Olsen M, Kong X, Louwe M, Lauritzen K, Schanke Y, Kaasboll O, et al.
Front Immunol . 2024 Apr; 15:1383505. PMID: 38686379
Acute myocardial infarction (MI) results in tissue damage to affected areas of the myocardium. The initial inflammatory response is the most damaging for residual cardiac function, while at later stages...
5.
Olsen M, Gregersen I, Sandanger O, Yang K, Sokolova M, Halvorsen B, et al.
JACC Basic Transl Sci . 2022 Feb; 7(1):84-98. PMID: 35128212
The pathogenesis of cardiovascular disease (CVD) is complex and multifactorial, and inflammation plays a central role. Inflammasomes are multimeric protein complexes that are activated in a 2-step manner in response...
6.
Holt M, Michelsen A, Shahini N, Bjorkelund E, Bendz C, Massey R, et al.
Front Immunol . 2022 Jan; 12:800978. PMID: 35003128
Objective: Dysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of...
7.
Louwe M, Olsen M, Kaasboll O, Yang K, Fosshaug L, Alfsnes K, et al.
JACC Basic Transl Sci . 2021 Jan; 5(12):1210-1224. PMID: 33426377
An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and...
8.
Sokolova M, Yang K, Hansen S, Louwe M, Kummen M, Hov J, et al.
Sci Rep . 2020 Dec; 10(1):21006. PMID: 33273482
Obesity-related diseases (e.g. type 2 diabetes mellitus and cardiovascular disorders) represent an increasing health problem worldwide. NLRP3 inflammasome activation may underlie obesity-induced inflammation and insulin resistance, and NLRP3 deficient mice...
9.
Shahini N, Schjalm C, Nilsson P, Holt M, S Ogaard J, Lien E, et al.
Biochem Biophys Res Commun . 2020 Jan; 523(4):867-873. PMID: 31955888
Inflammation is centrally involved in the development of cardiac hypertrophy and the processes of remodelling. The complement system and Toll-like receptor (TLR) family, two upstream arms of the innate immune...
10.
Holt M, Seim B, Ogaard J, Olsen M, Woldbaek P, Kvitting J, et al.
Open Heart . 2019 Dec; 6(2):e001098. PMID: 31798913
Objective: The aetiology of thoracic aortic aneurysm (TAA) is largely unknown, but inflammation is likely to play a central role in the pathogenesis. In this present study, we aim to...