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» Authors » Michihisa Kono

Michihisa Kono

Explore the profile of Michihisa Kono including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 32
Citations 108
Followers 0
Related Specialties
Oncology
General Surgery
Otorhinolaryngology
Top 10 Co-Authors
Takumi Kumai
Hiroki Komatsuda
Miki Takahara
Risa Wakisaka
Hidekiyo Yamaki
Akihiro Katada
Tatsuya Hayashi
Ryosuke Sato
Yasuaki Harabuchi
Kenzo Ohara
Published In
Head Neck
Cancer Immunol Immunother
Oncoimmunology
Clin Otolaryngol
Gan To Kagaku Ryoho
Affiliations
Soon will be listed here.
Recent Articles
1.
Empowering Communication in Medicine: A Workshop Approach to Improve Presentation Skills for Ear, Nose, and Throat Specialists
Tsuda T, Kumai T, Imoto Y, Kono M, Kishikawa T, Hosokawa K, et al.
Cureus . 2025 Jan; 16(12):e76342. PMID: 39867058
Introduction Effective communication is crucial for healthcare professionals, impacting patient care and interdisciplinary collaboration. However, medical education often lacks structured training in communication and presentation techniques. Herein, we evaluate the...
2.
Activation of fibroblasts by plasma cells via PDGF/PDGFR signaling in IgG4-related sialadenitis
Kitaoka T, Ohe R, Kabasawa T, Kaneko M, Sasahara N, Kono M, et al.
J Clin Exp Hematop . 2024 Sep; 64(3):223-231. PMID: 39343610
IgG4-related sialadenitis (IgG4-SA) is one of the IgG4-related disease. The histological features of IgG4-SA include dense lymphoplasmacytic infiltrates and fibrosis. This study aimed to reveal the involvement of plasma cells...
3.
Hypoxia-Targeted Immunotherapy with PD-1 Blockade in Head and Neck Cancer
Wakisaka R, Yamaki H, Kono M, Inoue T, Sato R, Komatsuda H, et al.
Cancers (Basel) . 2024 Sep; 16(17). PMID: 39272872
Intratumoral hypoxia is associated with tumor progression, aggressiveness, and therapeutic resistance in several cancers. Hypoxia causes cancer cells to experience replication stress, thereby activating DNA damage and repair pathways. MutT...
4.
Prognostic Value of the F-FDG PET/CT and Haematological Parameters in Head and Neck Cancer
Wakisaka R, Kumai T, Komatsuda H, Yamaki H, Kono M, Sato R, et al.
Clin Otolaryngol . 2024 Jul; 49(6):733-741. PMID: 38950901
Introduction: Fluorine 18-fluoro-glucose positron emission tomography/computed tomography (F-FDG PET/CT) is commonly used for the staging of head and neck cancer. This study aimed to evaluate the correlation between F-FDG PET/CT,...
5.
Combined approach for predicting the efficacy of nivolumab in head and neck carcinoma by tissue and soluble expressions of PD-L1 and PD-L2
Sato R, Komatsuda H, Inoue T, Wakisaka R, Kono M, Yamaki H, et al.
Head Neck . 2024 Apr; 46(9):2233-2243. PMID: 38665131
Background: Predictive biomarkers for nivolumab in recurrent or metastatic head and neck squamous cell carcinoma (RMHNSCC) have not yet been established. Methods: The tumor proportion score (TPS), combined positive score...
6.
Enhanced oral versus flank lymph node T cell response parallels anti-PD1 efficacy in head and neck cancer
Kono M, Saito S, Rokugo M, Egloff A, Uppaluri R
Oral Oncol . 2024 Apr; 152:106795. PMID: 38599127
Objectives: Understanding head and neck tissue specific immune responses is important for elucidating immunotherapy resistance mechanisms to head and neck squamous cell carcinoma (HNSCC). In this study, we aimed to...
7.
Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area
Kawamura I, Ohe R, Suzuki K, Kabasawa T, Kitaoka T, Takahara D, et al.
Cancer Cell Int . 2024 Mar; 24(1):107. PMID: 38486225
Background: A higher number of tumor buds in the invasive front of colorectal cancer (CRC) specimens has been shown to contribute to a poor prognosis in CRC patients. Because macrophages...
8.
Immunotherapy targeting tumor-associated antigen in a mouse model of head and neck cancer
Kono M, Wakisaka R, Komatsuda H, Hayashi R, Kumai T, Yamaki H, et al.
Head Neck . 2024 Feb; 46(8):2056-2067. PMID: 38390628
Background: The identification of epitope peptides from tumor-associated antigens (TAAs) is informative for developing tumor-specific immunotherapy. However, only a few epitopes have been detected in mouse TAAs of head and...
9.
Targeting Dendritic Cell Dysfunction to Circumvent Anti-PD1 Resistance in Head and Neck Cancer
Saito S, Kono M, Nguyen H, Egloff A, Messier C, Lizotte P, et al.
Clin Cancer Res . 2024 Feb; 30(9):1934-1944. PMID: 38372707
Purpose: Neoadjuvant anti-PD1 (aPD1) therapies are being explored in surgically resectable head and neck squamous cell carcinoma (HNSCC). Encouraging responses have been observed, but further insights into the mechanisms underlying...
10.
[Treatment Experience of Chemotherapy and Carbon-Ion Radiotherapy followed by Curative Conversion Surgery for Initially Locally Advanced Unresectable Pancreatic Cancer after Distal Gastrectomy]
Watanabe H, Sugawara S, Takahashi R, Ashitomi Y, Kawashiro S, Sato H, et al.
Gan To Kagaku Ryoho . 2024 Feb; 50(13):1959-1961. PMID: 38303264
Background: Carbon-ion radiotherapy(CIRT)has an advantage over conventional radiotherapy by its dose distribution and biological effect for locally advanced unresectable pancreatic cancer(UR-PC). Conversion surgery(CS)might be attempted for UR-PC with favorable response...