Michiel Van Speybroeck
Overview
Explore the profile of Michiel Van Speybroeck including associated specialties, affiliations and a list of published articles.
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17
Citations
256
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Recent Articles
1.
Bukara K, Schueller L, Rosier J, Martens M, Daems T, Verheyden L, et al.
Eur J Pharm Biopharm
. 2016 Sep;
108:220-225.
PMID: 27648957
Formulating poorly water soluble drugs using ordered mesoporous silica materials is an emerging approach to tackle solubility-related bioavailability problems. The current study was conducted to assess the bioavailability-enhancing potential of...
2.
Vialpando M, Smulders S, Bone S, Jager C, Vodak D, Van Speybroeck M, et al.
J Pharm Sci
. 2016 Apr;
105(9):2782-2793.
PMID: 27113473
This study investigates 3 amorphous technologies to improve the dissolution rate and oral bioavailability of flubendazole (FLU). The selected approaches are (1) a standard spray-dried dispersion with hydroxypropylmethylcellulose (HPMC) E5...
3.
Bouledjouidja A, Masmoudi Y, Van Speybroeck M, Schueller L, Badens E
Int J Pharm
. 2016 Jan;
499(1-2):1-9.
PMID: 26732521
Low oral bioavailability can be circumvented by the formulation of the poorly water soluble drug in ordered mesoporous silica (OMS-L-7). Fenofibrate is an orally administered, poorly water-soluble active pharmaceutical ingredient...
4.
Williams H, Van Speybroeck M, Augustijns P, Porter C
J Pharm Sci
. 2014 Apr;
103(6):1734-46.
PMID: 24740767
The current study determined the extent to which the desorption of lipid-based formulations (LBFs) from a mesoporous magnesium aluminometasilicate (Neusilin®-US2) carrier is governed by drug properties, LBF composition, and LBF-to-adsorbent...
5.
Van Speybroeck M, Williams H, Nguyen T, Anby M, Porter C, Augustijns P
Mol Pharm
. 2012 Aug;
9(9):2750-60.
PMID: 22870936
The purpose of the current study was to provide a mechanistic basis for in vitro and in vivo performance differences between lipid-based formulations solidified by adsorption onto a high surface...
6.
Van Speybroeck M, Mellaerts R, Do Thi T, Martens J, Van Humbeeck J, Annaert P, et al.
J Pharm Sci
. 2011 Jul;
100(11):4864-76.
PMID: 21766312
This study aimed to assess the pharmaceutical performance of formulations consisting of either indomethacin or glibenclamide and the ordered mesoporous silica material SBA-15. Both compounds were loaded on SBA-15 via...
7.
Do T, Van Speybroeck M, Mols R, Annaert P, Martens J, Van Humbeeck J, et al.
Int J Pharm
. 2011 May;
414(1-2):118-24.
PMID: 21596119
The performance of four different lipid-based (Tween 80-Captex 200P, Tween 80-Capmul MCM, Tween 80-Caprol 3GO and Tween 80-soybean oil) and one commercially available micronized formulation (Lipanthyl Micronized(®)) of the lipophilic...
8.
Mellaerts R, Roeffaers M, Houthoofd K, Van Speybroeck M, De Cremer G, Jammaer J, et al.
Phys Chem Chem Phys
. 2010 Dec;
13(7):2706-13.
PMID: 21152589
The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water inside SBA-15 ordered mesoporous silica material....
9.
Van Speybroeck M, Mellaerts R, Mols R, Do Thi T, Martens J, Van Humbeeck J, et al.
Eur J Pharm Sci
. 2010 Sep;
41(5):623-30.
PMID: 20850527
The aim of the present study was to evaluate the effect of release rate from ordered mesoporous silica materials on the rate and extent of absorption of the poorly soluble...
10.
Do Thi T, Nauwelaerts K, Froeyen M, Baudemprez L, Van Speybroeck M, Augustijns P, et al.
J Pharm Sci
. 2010 Jul;
99(9):3863-73.
PMID: 20665846
Complexation in solution between methylprednisolone and three different cyclodextrins [2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), gamma-cyclodextrin (gamma-CD), and 2-hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD)] was studied using phase solubility analysis, one and two-dimensional (1)H-NMR and molecular modeling. Estimates...