Michelle L McCully
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Explore the profile of Michelle L McCully including associated specialties, affiliations and a list of published articles.
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17
Citations
507
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Recent Articles
1.
Paterson R, La Manna M, Arena De Souza V, Walker A, Gibbs-Howe D, Kulkarni R, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(19):e2318003121.
PMID: 38691588
Peptides presented by HLA-E, a molecule with very limited polymorphism, represent attractive targets for T cell receptor (TCR)-based immunotherapies to circumvent the limitations imposed by the high polymorphism of classical...
2.
Wallace Z, Kopycinski J, Yang H, McCully M, Eggeling C, Chojnacki J, et al.
Sci Rep
. 2022 Nov;
12(1):18366.
PMID: 36319836
T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8 T cells, which may remain dysfunctional despite...
3.
Curnock A, Bossi G, Kumaran J, Bawden L, Figueiredo R, Tawar R, et al.
JCI Insight
. 2021 Sep;
6(20).
PMID: 34491911
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area...
4.
Robinson R, McMurran C, McCully M, Cole D
FEBS J
. 2021 Feb;
288(21):6159-6173.
PMID: 33624424
Immunotherapy approaches that target peptide-human leukocyte antigen (pHLA) complexes are becoming highly attractive because of their potential to access virtually all foreign and cellular proteins. For this reason, there has...
5.
Fergusson J, Wallace Z, Connolly M, Woon A, Suckling R, Hine D, et al.
Hepatology
. 2020 Aug;
72(5):1528-1540.
PMID: 32770836
Background And Aims: Therapies for chronic hepatitis B virus (HBV) infection are urgently needed because of viral integration, persistence of viral antigen expression, inadequate HBV-specific immune responses, and treatment regimens...
6.
Coles C, Mulvaney R, Malla S, Walker A, Smith K, Lloyd A, et al.
J Immunol
. 2020 Feb;
204(7):1943-1953.
PMID: 32102902
The molecular rules driving TCR cross-reactivity are poorly understood and, consequently, it is unclear the extent to which TCRs targeting the same Ag recognize the same off-target peptides. We determined...
7.
McCully M, Kouzeli A, Moser B
Trends Immunol
. 2018 Jul;
39(9):734-747.
PMID: 30001872
Cellular immunity is governed by a complex network of migratory cues that enable appropriate immune cell responses in a timely and spatially controlled fashion. This review focuses on the chemokines...
8.
McCully M, Ladell K, Andrews R, Jones R, Miners K, Roger L, et al.
J Immunol
. 2018 Feb;
200(5):1639-1650.
PMID: 29427415
Human skin harbors two major T cell compartments of equal size that are distinguished by expression of the chemokine receptor CCR8. In vitro studies have demonstrated that CCR8 expression is...
9.
Collins P, McCully M, Martinez-Munoz L, Santiago C, Wheeldon J, Caucheteux S, et al.
FASEB J
. 2017 Apr;
31(7):3084-3097.
PMID: 28360196
The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed in blood and tissue cells, and is essential during embryogenesis and...
10.
McCully M, Collins P, Hughes T, Thomas C, Billen J, ODonnell V, et al.
J Immunol
. 2015 May;
195(1):96-104.
PMID: 26002980
The localization of memory T cells to human skin is essential for long-term immune surveillance and the maintenance of barrier integrity. The expression of CCR8 during naive T cell activation...