Michelle E Stewart
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Explore the profile of Michelle E Stewart including associated specialties, affiliations and a list of published articles.
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8
Citations
306
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Recent Articles
1.
McCabe C, Price P, Codner G, Allan A, Caulder A, Christou S, et al.
PLoS Genet
. 2024 Mar;
20(3):e1011187.
PMID: 38457464
Background: Recent developments in CRISPR/Cas9 genome-editing tools have facilitated the introduction of precise alleles, including genetic intervals spanning several kilobases, directly into the embryo. However, the introduction of donor templates,...
2.
Wotton J, Peterson E, Flenniken A, Bains R, Veeraragavan S, Bower L, et al.
Pain
. 2022 May;
163(6):1139-1157.
PMID: 35552317
Identifying the genetic determinants of pain is a scientific imperative given the magnitude of the global health burden that pain causes. Here, we report a genetic screen for nociception, performed...
3.
Codner G, Mianne J, Caulder A, Loeffler J, Fell R, King R, et al.
BMC Biol
. 2018 Jun;
16(1):70.
PMID: 29925374
Background: Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing have led to the use of long single-stranded DNA (lssDNA) molecules for generating conditional...
4.
Meehan T, Conte N, West D, Jacobsen J, Mason J, Warren J, et al.
Nat Genet
. 2017 Jun;
49(8):1231-1238.
PMID: 28650483
Although next-generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies are still limited by a lack of knowledge of the...
5.
Mianne J, Codner G, Caulder A, Fell R, Hutchison M, King R, et al.
Methods
. 2017 Apr;
121-122:68-76.
PMID: 28363792
The application of CRISPR/Cas9 technology has revolutionised genetics by greatly enhancing the efficacy of genome editing in the early embryo. Furthermore, the system has enabled the generation of allele types...
6.
Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance
Hugill A, Stewart M, Yon M, Probert F, Cox I, Hough T, et al.
Biol Open
. 2015 Oct;
4(11):1367-75.
PMID: 26432886
Tryptophan metabolites have been linked in observational studies with type 2 diabetes, cognitive disorders, inflammation and immune system regulation. A rate-limiting enzyme in tryptophan conversion is arylformamidase (Afmid), and a...
7.
Thoby-Brisson M, Bouvier J, Glasco D, Stewart M, Dean C, Murdoch J, et al.
PLoS One
. 2012 Feb;
7(2):e31140.
PMID: 22363567
The proper development and maturation of neuronal circuits require precise migration of component neurons from their birthplace (germinal zone) to their final positions. Little is known about the effects of...
8.
Patterson V, Damrau C, Paudyal A, Reeve B, Grimes D, Stewart M, et al.
Hum Mol Genet
. 2009 Feb;
18(10):1719-39.
PMID: 19223390
The mammalian Sonic hedgehog (Shh) signalling pathway is essential for embryonic development and the patterning of multiple organs. Disruption or activation of Shh signalling leads to multiple birth defects, including...