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Michela Botta

Explore the profile of Michela Botta including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 21
Citations 324
Followers 0
Related Specialties
Pulmonary Medicine
General Medicine
Cardiology & Vascular Diseases
Top 10 Co-Authors
Frederique Paulus
Marcus J Schultz
Ary Serpa Neto
Anissa M Tsonas
Janneke Horn
Lieuwe D J Bos
David M P van Meenen
Serena Bergerone
Fiorenzo Gaita
Pim L J van der Heiden
Published In
J Clin Med
Lancet Respir Med
Am J Trop Med Hyg
Ann Transl Med
Respir Res
Affiliations
Soon will be listed here.
Recent Articles
1.
Epidemiology, Ventilation Management, and Outcomes in Invasively Ventilated Coronavirus Disease 2019 Patients: An Analysis of Four Observational Studies in Four Countries on Two Continents
Blok S, Pisani L, Estenssoro E, Ferreira J, Botta M, Motos A, et al.
Am J Trop Med Hyg . 2025 Jan; PMID: 39842032
Epidemiology, ventilator management, and outcomes in patients with acute respiratory distress syndrome (ARDS) because of coronavirus disease 2019 (COVID-19) have been described extensively but have never been compared between countries....
2.
Effects of Automated Versus Conventional Ventilation on Quality of Oxygenation-A Substudy of a Randomized Crossover Clinical Trial
Botta M, van Meenen D, van Leijsen T, Rogmans J, List S, van der Heiden P, et al.
J Clin Med . 2025 Jan; 14(1. PMID: 39797125
: Attaining adequate oxygenation in critically ill patients undergoing invasive ventilation necessitates intense monitoring through pulse oximetry (SpO) and frequent manual adjustments of ventilator settings like the fraction of inspired...
3.
Epidemiology, ventilation management and outcomes of COVID-19 ARDS patients versus patients with ARDS due to pneumonia in the Pre-COVID era
van der Ven F, Blok S, Azevedo L, Bellani G, Botta M, Estenssoro E, et al.
Respir Res . 2024 Aug; 25(1):312. PMID: 39153979
Background: Ventilation management may differ between COVID-19 ARDS (COVID-ARDS) patients and patients with pre-COVID ARDS (CLASSIC-ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC-ARDS also exist...
4.
Effect of automated versus conventional ventilation on mechanical power of ventilation-A randomized crossover clinical trial
Buiteman-Kruizinga L, Serpa Neto A, Botta M, List S, de Boer B, van Velzen P, et al.
PLoS One . 2024 Jul; 19(7):e0307155. PMID: 39078857
Introduction: Mechanical power of ventilation, a summary parameter reflecting the energy transferred from the ventilator to the respiratory system, has associations with outcomes. INTELLiVENT-Adaptive Support Ventilation is an automated ventilation...
5.
Lung Ultrasound to Determine the Effect of Lower vs. Higher PEEP on Lung Aeration in Patients without ARDS-A Substudy of a Randomized Clinical Trial
Zimatore C, Algera A, Botta M, Pierrakos C, Serpa Neto A, Grasso S, et al.
Diagnostics (Basel) . 2023 Jun; 13(12). PMID: 37370885
Background: Ventilation with lower positive end-expiratory pressure (PEEP) may cause loss of lung aeration in critically ill invasively ventilated patients. This study investigated whether a systematic lung ultrasound (LUS) scoring...
6.
Age-related changes in plasma biomarkers and their association with mortality in COVID-19
Michels E, van Amstel R, van Linge C, Schuurman A, Reijnders T, Sulzer T, et al.
Eur Respir J . 2023 Apr; 62(1). PMID: 37080568
Background: Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial in these patients. The biological substrate behind these observations is unknown. The aim...
7.
Oxygen Consumption with High-Flow Nasal Oxygen versus Mechanical Ventilation- An International Multicenter Observational Study in COVID-19 Patients (PROXY-COVID)
Botta M, Caritg O, van Meenen D, Pacheco A, Tsonas A, Mooij W, et al.
Am J Trop Med Hyg . 2023 Mar; 108(5):1035-1041. PMID: 36972693
The COVID-19 pandemic led to local oxygen shortages worldwide. To gain a better understanding of oxygen consumption with different respiratory supportive therapies, we conducted an international multicenter observational study to...
8.
Myocardial Function during Ventilation with Lower versus Higher Positive End-Expiratory Pressure in Patients without ARDS
Algera A, Pierrakos C, Botta M, Zimatore C, Pisani L, Tuinman P, et al.
J Clin Med . 2022 May; 11(9). PMID: 35566435
The aim of this study was to investigate whether lower PEEP (positive end-expiratory pressure) had beneficial effects on myocardial function among intensive care unit (ICU) patients without acute respiratory distress...
9.
Effect of Automated Closed-loop ventilation versus convenTional VEntilation on duration and quality of ventilation in critically ill patients (ACTiVE) - study protocol of a randomized clinical trial
Botta M, Tsonas A, Sinnige J, de Bie A, Bindels A, Ball L, et al.
Trials . 2022 Apr; 23(1):348. PMID: 35461264
Background: INTELLiVENT-Adaptive Support Ventilation (ASV) is a fully automated closed-loop mode of ventilation for use in critically ill patients. Evidence for benefit of INTELLiVENT-ASV in comparison to ventilation that is...
10.
Clinical characteristics, physiological features, and outcomes associated with hypercapnia in patients with acute hypoxemic respiratory failure due to COVID-19---insights from the PRoVENT-COVID study
Tsonas A, Botta M, Horn J, Morales-Quinteros L, Artigas A, Schultz M, et al.
J Crit Care . 2022 Mar; 69:154022. PMID: 35339900
Purpose: We determined the incidence of hypercapnia and associations with outcome in invasively ventilated COVID-19 patients. Methods: Posthoc analysis of a national, multicenter, observational study in 22 ICUs. Patients were...