Michal O Nowicki
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Explore the profile of Michal O Nowicki including associated specialties, affiliations and a list of published articles.
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42
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2076
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Recent Articles
1.
Jimenez-Macias J, Vaughn-Beaucaire P, Bharati A, Xu Z, Forrest M, Hong J, et al.
Sci Adv
. 2025 Feb;
11(9):eadr1481.
PMID: 40009687
Efficient drug delivery to glioblastoma (GBM) is a major obstacle as the blood-brain barrier (BBB) and the blood-tumor barrier (BTB) prevent passage of the majority of chemotherapies into the brain....
2.
Jimenez-Macias J, Vaughn-Beaucaire P, Bharati A, Xu Z, Forrest M, Hong J, et al.
bioRxiv
. 2024 Sep;
PMID: 39253453
Glioblastoma (GBM) is the most common malignant primary brain tumor. GBM has an extremely poor prognosis and new treatments are badly needed. Efficient drug delivery to GBM is a major...
3.
Ling A, Solomon I, Landivar A, Nakashima H, Woods J, Santos A, et al.
Nature
. 2023 Oct;
623(7985):157-166.
PMID: 37853118
Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM). Here we report the results of a first-in-human phase...
4.
Koch M, Zdioruk M, Nowicki M, Hoetker M, Herbert Z, Barone F, et al.
Front Med (Lausanne)
. 2023 May;
10:1140352.
PMID: 37228396
Rationale: CAN-2409 is a locally delivered oncolytic therapy, which results in vaccination against the injected tumor. CAN-2409 consists of a non-replicating adenovirus armed with the Herpes virus thymidine kinase, which...
5.
Marloye M, Inam H, Moore C, Mertens T, Ingels A, Koch M, et al.
Inorg Chem Front
. 2022 Oct;
9(11):2594-2607.
PMID: 36311556
We disclose novel amphiphilic ruthenium and osmium complexes that auto-assemble into nanomedicines with potent antiproliferative activity by inhibition of mitochondrial respiration. The self-assembling units were rationally designed from the [M(-cymene)(1,10-phenanthroline)Cl]PF...
6.
Koch M, Zdioruk M, Nowicki M, Griffith A, Aguilar-Cordova E, Aguilar L, et al.
Mol Ther Oncolytics
. 2022 Aug;
26:275-288.
PMID: 36032633
CAN-2409 is a replication-deficient adenovirus encoding herpes simplex virus (HSV) thymidine kinase (tk) currently in clinical trials for treatment of glioblastoma. The expression of tk in transduced cancer cells results...
7.
Berger G, Knelson E, Jimenez-Macias J, Nowicki M, Han S, Panagioti E, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(28):e2111003119.
PMID: 35787058
Immunotherapy has had a tremendous impact on cancer treatment in the past decade, with hitherto unseen responses at advanced and metastatic stages of the disease. However, the aggressive brain tumor...
8.
Ketchen S, Gamboa-Esteves F, Lawler S, Nowicki M, Rohwedder A, Knipp S, et al.
Biomedicines
. 2022 Jan;
10(1).
PMID: 35052688
Cancer cell invasion is a precondition for tumour metastasis and represents one of the most devastating characteristics of cancer. The development of drugs targeting cell migration, known as migrastatics, may...
9.
Koch M, Zdioruk M, Nowicki M, Griffith A, Aguilar E, Aguilar L, et al.
J Immunother Cancer
. 2022 Jan;
10(1).
PMID: 35017150
Background: Intratumoral viral oncolytic immunotherapy is a promising new approach for the treatment of a variety of solid cancers. CAN-2409 is a replication-deficient adenovirus that delivers herpes simplex virus thymidine...
10.
Krenzlin H, Zdioruk M, Nowicki M, Finkelberg T, Keric N, Lemmermann N, et al.
Cancer Lett
. 2021 May;
513:26-35.
PMID: 33989707
Cytomegalovirus (CMV) is widespread in humans and has been implicated in glioblastoma (GBM) and other tumors. However, the role of CMV in GBM remains poorly understood and the mechanisms involved...