Michal Caspi
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Explore the profile of Michal Caspi including associated specialties, affiliations and a list of published articles.
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23
Citations
424
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Recent Articles
11.
Kariv R, Caspi M, Fliss-Isakov N, Shorer Y, Shor Y, Rosner G, et al.
Int J Cancer
. 2019 Jul;
146(4):1064-1074.
PMID: 31283021
As a large number of cancers are caused by nonsense mutations in key genes, read-through of these mutations to restore full-length protein expression is a potential therapeutic strategy. Mutations in...
12.
Margalit S, Avraham S, Shahal T, Michaeli Y, Gilat N, Magod P, et al.
Int J Cancer
. 2019 Jun;
146(1):115-122.
PMID: 31211411
Epigenetic transformations may provide early indicators for cancer and other disease. Specifically, the amount of genomic 5-hydroxymethylcytosine (5-hmC) was shown to be globally reduced in a wide range of cancers....
13.
Lahav-Ariel L, Caspi M, Nadar-Ponniah P, Zelikson N, Hofmann I, Hanson K, et al.
FASEB J
. 2018 Dec;
33(4):4729-4740.
PMID: 30592649
The adherens junctions (AJs) and tight junctions (TJs) provide critical adhesive contacts between neighboring epithelial cells and are crucial for epithelial adhesion, integrity, and barrier functions in a wide variety...
14.
Globus O, Evron T, Caspi M, Siman-Tov R, Rosin-Arbesfeld R
Sci Rep
. 2017 Dec;
7(1):17995.
PMID: 29269789
Different cancer types as well as many other diseases are caused by aberrant activation of the canonical Wnt signal transduction pathway, and it is especially implicated in the development and...
15.
Yedid N, Kalma Y, Malcov M, Amit A, Kariv R, Caspi M, et al.
BMC Cancer
. 2016 Dec;
16(1):952.
PMID: 28010732
Background: Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis...
16.
Caspi M, Firsow A, Rajkumar R, Skalka N, Moshkovits I, Munitz A, et al.
J Mol Med (Berl)
. 2016 Feb;
94(4):483.
PMID: 26897011
No abstract available.
17.
Caspi M, Firsow A, Rajkumar R, Skalka N, Moshkovitz I, Munitz A, et al.
J Mol Med (Berl)
. 2015 Dec;
94(4):469-82.
PMID: 26620677
Unlabelled: A large number of human diseases are caused by nonsense mutations. These mutations result in premature protein termination and the expression of truncated, usually nonfunctional products. A promising therapeutic...
18.
Caspi M, Perry G, Skalka N, Meisel S, Firsow A, Amit M, et al.
Mol Cancer
. 2014 Jul;
13:164.
PMID: 24993527
The Wnt signaling pathway is an evolutionary conserved system, having pivotal roles during animal development. When over-activated, this signaling pathway is involved in cancer initiation and progression. The canonical Wnt...
19.
Dovrat S, Caspi M, Zilberberg A, Lahav L, Firsow A, Gur H, et al.
Mol Oncol
. 2014 Apr;
8(5):894-911.
PMID: 24721736
Aberrant activation of the canonical Wnt signal transduction pathway is involved in a large number of human diseases. β-catenin, the key effector protein of the canonical Wnt pathway, functions in...
20.
Hay-Koren A, Caspi M, Zilberberg A, Rosin-Arbesfeld R
Mol Biol Cell
. 2010 Dec;
22(3):399-411.
PMID: 21118991
Wnt/β-catenin signaling plays a central role in development and is also involved in a diverse array of diseases. β-Catenin activity is tightly regulated via a multiprotein complex that includes the...