Michael Waisberg
Overview
Explore the profile of Michael Waisberg including associated specialties, affiliations and a list of published articles.
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19
Citations
1167
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Recent Articles
1.
Gordon E, Hart G, Tran T, Waisberg M, Akkaya M, Kim A, et al.
Proc Natl Acad Sci U S A
. 2015 Oct;
112(42):13075-80.
PMID: 26438846
The most deadly complication of Plasmodium falciparum infection is cerebral malaria (CM) with a case fatality rate of 15-25% in African children despite effective antimalarial chemotherapy. There are no adjunctive...
2.
Skinner J, Huang C, Waisberg M, Felgner P, Doumbo O, Ongoiba A, et al.
Infect Immun
. 2015 Aug;
83(11):4229-36.
PMID: 26283330
Malaria elimination efforts would benefit from vaccines that block transmission of Plasmodium falciparum gametocytes from humans to mosquitoes. A clear understanding of gametocyte-specific antibody responses in exposed populations could help...
3.
Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria
Gordon E, Hart G, Tran T, Waisberg M, Akkaya M, Skinner J, et al.
mBio
. 2015 Jun;
6(3):e00725.
PMID: 26037126
Unlabelled: Malaria is an infectious disease caused by parasites of several Plasmodium spp. Cerebral malaria (CM) is a common form of severe malaria resulting in nearly 700,000 deaths each year...
4.
Zinocker S, Schindler C, Skinner J, Rogosch T, Waisberg M, Schickel J, et al.
J Immunol
. 2015 Jan;
194(3):929-39.
PMID: 25556245
Immunity to Plasmodium falciparum malaria is naturally acquired in individuals living in malaria-endemic areas of Africa. Abs play a key role in mediating this immunity; however, the acquisition of the...
5.
Waisberg M, Molina-Cruz A, Mizurini D, Gera N, Sousa B, Ma D, et al.
PLoS Pathog
. 2014 Sep;
10(9):e1004338.
PMID: 25211214
Background: Invasion of mosquito salivary glands (SGs) by Plasmodium falciparum sporozoites is an essential step in the malaria life cycle. How infection modulates gene expression, and affects hematophagy remains unclear....
6.
Crompton P, Moebius J, Portugal S, Waisberg M, Hart G, Garver L, et al.
Annu Rev Immunol
. 2014 Mar;
32:157-87.
PMID: 24655294
Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa. Malaria imposes a huge health burden...
7.
Francischetti I, Gordon E, Bizzarro B, Gera N, Andrade B, Oliveira F, et al.
PLoS One
. 2014 Mar;
9(2):e87140.
PMID: 24586264
Background: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. Methods And Findings: We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and...
8.
Mourao M, Bitar M, Pereira Lobo F, Peconick A, Grynberg P, Prosdocimi F, et al.
Mem Inst Oswaldo Cruz
. 2013 Sep;
108(6):707-17.
PMID: 24037192
Schistosomiasis is a major neglected tropical disease caused by trematodes from the genus Schistosoma. Because schistosomes exhibit a complex life cycle and numerous mechanisms for regulating gene expression, it is...
9.
Waisberg M, Lin C, Huang C, Pena M, Orandle M, Bolland S, et al.
PLoS One
. 2013 May;
8(5):e62820.
PMID: 23675429
Severe malaria, including cerebral malaria (CM) and placental malaria (PM), have been recognized to have many of the features of uncontrolled inflammation. We recently showed that in mice genetic susceptibility...
10.
Waisberg M, Cerqueira G, Yager S, Francischetti I, Lu J, Gera N, et al.
Proc Natl Acad Sci U S A
. 2012 Mar;
109(14):5429-34.
PMID: 22431641
The malaria parasite, Plasmodium falciparum, and the human immune system have coevolved to ensure that the parasite is not eliminated and reinfection is not resisted. This relationship is likely mediated...