Michael W Knitz
Overview
Explore the profile of Michael W Knitz including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
163
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0
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Recent Articles
11.
Piper M, Hoen M, Darragh L, Knitz M, Nguyen D, Gadwa J, et al.
Cancer Cell
. 2023 Apr;
41(5):950-969.e6.
PMID: 37116489
In pancreatic ductal adenocarcinoma (PDAC) patients, we show that response to radiation therapy (RT) is characterized by increased IL-2Rβ and IL-2Rγ along with decreased IL-2Rα expression. The bispecific PD1-IL2v is...
12.
Darragh L, Gadwa J, Pham T, Van Court B, Neupert B, Olimpo N, et al.
Nat Commun
. 2022 Nov;
13(1):7015.
PMID: 36385142
In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease...
13.
Bhatia S, Nguyen D, Darragh L, Van Court B, Sharma J, Knitz M, et al.
Nat Commun
. 2022 Jun;
13(1):3535.
PMID: 35725568
Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of targeting EphB4 and ephrinB2 in head and neck squamous cell...
14.
Bickett T, Knitz M, Piper M, Oweida A, Gadwa J, Darragh L, et al.
Mol Ther
. 2021 Nov;
30(3):1149-1162.
PMID: 34793974
STAT3 signaling has been shown to regulate cellular function and cytokine production in the tumor microenvironment (TME). Within the head and neck squamous cell carcinoma (HNSCC) TME, we previously showed...
15.
Knitz M, Darragh L, Bickett T, Bhatia S, Bukkapatnam S, Gadwa J, et al.
Cancer Immunol Immunother
. 2021 Sep;
71(5):1049-1061.
PMID: 34559306
Resistance to radiation therapy (RT) remains an obstacle in HPV-negative head and neck squamous cell carcinomas (HNSCCs)-even with a combined RT-immunotherapy approach. Jak-Stat proteins have long been studied for both...
16.
Knitz M, Bickett T, Darragh L, Oweida A, Bhatia S, Van Court B, et al.
J Immunother Cancer
. 2021 Apr;
9(4).
PMID: 33883256
Background: Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint...
17.
Mueller A, Piper M, Goodspeed A, Bhuvane S, Williams J, Bhatia S, et al.
Cancer Res
. 2021 Feb;
81(12):3255-3269.
PMID: 33526513
Stromal fibrosis activates prosurvival and proepithelial-to-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma (PDAC). In patient tumors treated with neoadjuvant stereotactic body radiation therapy (SBRT), we found upregulation of fibrosis,...