Michael W Clarkson
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Explore the profile of Michael W Clarkson including associated specialties, affiliations and a list of published articles.
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19
Citations
865
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0
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Recent Articles
1.
Zerio C, Sivinski J, Wijeratne E, Xu Y, Ngo D, Ambrose A, et al.
J Med Chem
. 2022 Dec;
66(1):913-933.
PMID: 36577036
A pulldown using a biotinylated natural product of interest in the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), identified the bromodomain and extra-terminal domain (BET) family of proteins (BRD2, BRD3, and...
2.
Torgeson K, Clarkson M, Granata D, Lindorff-Larsen K, Page R, Peti W
Sci Adv
. 2022 Aug;
8(31):eabo5546.
PMID: 35921420
Homologous enzymes often exhibit different catalytic rates despite a fully conserved active site. The canonical view is that an enzyme sequence defines its structure and function and, more recently, that...
3.
Schoenle M, Li Y, Yuan M, Clarkson M, Wilson I, Peti W, et al.
J Am Chem Soc
. 2021 May;
143(21):7930-7934.
PMID: 34018723
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into cells is a complex process that involves (1) recognition of the host entry receptor, angiotensin-converting enzyme 2 (ACE2), by the...
4.
Torgeson K, Clarkson M, Kumar G, Page R, Peti W
J Biol Chem
. 2020 Aug;
295(40):13829-13837.
PMID: 32737198
Protein-tyrosine phosphatase 1B (PTP1B) is the canonical enzyme for investigating how distinct structural elements influence enzyme catalytic activity. Although it is recognized that dynamics are essential for PTP1B function, the...
5.
Lixa C, Clarkson M, Iqbal A, Moon T, Almeida F, Peti W, et al.
Biochemistry
. 2019 Oct;
58(41):4183-4194.
PMID: 31566355
Cellular retinoic acid-binding protein 2 (CRABP2) delivers retinoic acid (atRA) to retinoic acid receptors (RARs), allowing for the activation of specific gene transcription. The structural similarities between free and atRA-bound...
6.
Kumar G, Clarkson M, Kunze M, Granata D, Wand A, Lindorff-Larsen K, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(18):4655-4660.
PMID: 29666261
Mitogen-activated protein kinases, which include p38, are essential for cell differentiation and autophagy. The current model for p38 activation involves activation-loop phosphorylation with subsequent substrate binding leading to substrate phosphorylation....
7.
Otten R, Liu L, Kenner L, Clarkson M, Mavor D, Tawfik D, et al.
Nat Commun
. 2018 Apr;
9(1):1314.
PMID: 29615624
Rational design and directed evolution have proved to be successful approaches to increase catalytic efficiencies of both natural and artificial enzymes. Protein dynamics is recognized as important, but due to...
8.
Villali J, Pontiggia F, Clarkson M, Hagan M, Kern D
J Mol Biol
. 2014 Jan;
426(7):1554-67.
PMID: 24406745
The dominant theory on the mechanism of response regulators activation in two-component bacterial signaling systems is the "Y-T coupling" mechanism, wherein the χ1 rotameric state of a highly conserved aromatic...
9.
Koveal D, Clarkson M, Wood T, Page R, Peti W
J Mol Biol
. 2013 Mar;
425(12):2219-31.
PMID: 23524133
Tyrosine phosphatase related to biofilm formation A (TpbA) is a periplasmic dual-specificity phosphatase (DUSP) that controls biofilm formation in the pathogenic bacterium Pseudomonas aeruginosa. While DUSPs are known to regulate...
10.
Morrison E, DeKoster G, Dutta S, Vafabakhsh R, Clarkson M, Bahl A, et al.
Nature
. 2011 Dec;
481(7379):45-50.
PMID: 22178925
Small multidrug resistance transporters provide an ideal system to study the minimal requirements for active transport. EmrE is one such transporter in Escherichia coli. It exports a broad class of...