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Michael Valenzuela

Explore the profile of Michael Valenzuela including associated specialties, affiliations and a list of published articles. Areas
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Articles 59
Citations 2799
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Recent Articles
21.
Radd-Vagenas S, Fiatarone Singh M, Inskip M, Mavros Y, Gates N, Wilson G, et al.
Br J Nutr . 2018 Nov; 120(10):1189-1200. PMID: 30401000
Dementia is a leading cause of morbidity and mortality without pharmacologic prevention or cure. Mounting evidence suggests that adherence to a Mediterranean dietary pattern may slow cognitive decline, and is...
22.
Stern Y, Arenaza-Urquijo E, Bartres-Faz D, Belleville S, Cantilon M, Chetelat G, et al.
Alzheimers Dement . 2018 Sep; 16(9):1305-1311. PMID: 30222945
Several concepts, which in the aggregate get might be used to account for "resilience" against age- and disease-related changes, have been the subject of much research. These include brain reserve,...
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Chan D, Shafto M, Kievit R, Matthews F, Spink M, Valenzuela M, et al.
Neurobiol Aging . 2018 Jul; 70:180-183. PMID: 30025291
This study tested the hypothesis that mid-life intellectual, physical, and social activities contribute to cognitive reserve (CR). Two hundred five individuals (196 with magnetic resonance imaging) aged 66-88 years from...
25.
Baker K, Georgiou-Karistianis N, Lampit A, Valenzuela M, Gibson S, Giummarra M
Pain . 2018 Feb; 159(4):644-655. PMID: 29447133
Chronic pain is associated with reduced efficiency of cognitive performance, and few studies have investigated methods of remediation. We trialled a computerised cognitive training protocol to determine whether it could...
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Duncan T, Lowe A, Sidhu K, Sachdev P, Lewis T, Lin R, et al.
Stem Cell Reports . 2017 Aug; 9(2):557-570. PMID: 28793248
Repopulation of brain circuits by neural precursors is a potential therapeutic strategy for neurodegenerative disorders; however, choice of cell is critical. Previously, we introduced a two-step culture system that generates...
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Duncan T, Valenzuela M
Stem Cell Res Ther . 2017 May; 8(1):111. PMID: 28494803
Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal...
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Mavros Y, Gates N, Wilson G, Jain N, Meiklejohn J, Brodaty H, et al.
J Am Geriatr Soc . 2017 Mar; 65(3):550-559. PMID: 28304092
Objectives: To determine whether improvements in aerobic capacity (VO ) and strength after progressive resistance training (PRT) mediate improvements in cognitive function. Design: Randomized, double-blind, double-sham, controlled trial. Setting: University...
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Duncan T, Lowe A, Dalton M, Valenzuela M
J Vis Exp . 2016 Dec; (117). PMID: 27929471
The rate of neurogenesis within the adult hippocampus has been shown to vary across mammalian species. The canine hippocampus, demonstrating a structural intermediacy between the rodent and human hippocampi, is...
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Hill N, Mowszowski L, Naismith S, Chadwick V, Valenzuela M, Lampit A
Am J Psychiatry . 2016 Nov; 174(4):329-340. PMID: 27838936
Objective: Previous meta-analyses indicate that computerized cognitive training (CCT) is a safe and efficacious intervention for cognition in older adults. However, efficacy varies across populations and cognitive domains, and little...