Michael Spoerner
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Explore the profile of Michael Spoerner including associated specialties, affiliations and a list of published articles.
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28
Citations
497
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Recent Articles
1.
Girard E, Lopes P, Spoerner M, Dhaussy A, Prange T, Kalbitzer H, et al.
Chemistry
. 2024 Apr;
30(35):e202400304.
PMID: 38647362
In this work, we experimentally investigate the potency of high pressure to drive a protein toward an excited state where an inhibitor targeted for this state can bind. Ras proteins...
2.
Girard E, Lopes P, Spoerner M, Dhaussy A, Prange T, Kalbitzer H, et al.
Chem Sci
. 2022 Mar;
13(7):2001-2010.
PMID: 35308861
In this work, we experimentally investigate the allosteric transitions between conformational states on the Ras oncogene protein using high pressure crystallography. Ras protein is a small GTPase involved in central...
3.
Karl M, Spoerner M, Pham T, Narayanan S, Kremer W, Kalbitzer H
Biophys Chem
. 2017 Apr;
231:50-54.
PMID: 28395928
High pressure NMR spectroscopy is a powerful method for identifying rare conformational states of proteins from the pressure response of their chemical shifts. Many proteins have bound adenine nucleotides at...
4.
Spoerner M, Karl M, Lopes P, Hoering M, Loeffel K, Nuehs A, et al.
J Biomol NMR
. 2016 Dec;
67(1):1-13.
PMID: 28012125
The P NMR pressure response of guanine nucleotides bound to proteins has been studied in the past for characterizing the pressure perturbation of conformational equilibria. The pressure response of the...
5.
Spoerner M, Wichard T, Bachhuber T, Stratmann J, Oertel W
J Phycol
. 2016 Mar;
48(6):1433-47.
PMID: 27009994
Axenic Ulva mutabilis gametes develop parthenogenetically into callus-like colonies consisting of undifferentiated cells without normal cell walls. From the accompanying microbial flora of established laboratory strains of U. mutabilis with...
6.
Kalbitzer H, Spoerner M
Enzymes
. 2014 Jul;
33 Pt A:69-94.
PMID: 25033801
Oncogenic mutations in the Ras (rat sarcoma) protein lead to a permanent activation of the Ras pathway and are found in approximately 30% of all human tumors. During signal transduction,...
7.
Rosnizeck I, Filchtinski D, Lopes R, Kieninger B, Herrmann C, Kalbitzer H, et al.
Biochemistry
. 2014 May;
53(24):3867-78.
PMID: 24866928
The small GTPase Ras is an essential component of signal transduction pathways within the cell, controlling proliferation, differentiation, and apoptosis. Only in the GTP-bound form does Ras interact strongly with...
8.
Zeraik A, Pereira H, Santos Y, Brandao-Neto J, Spoerner M, Santos M, et al.
J Biol Chem
. 2014 Jan;
289(11):7799-811.
PMID: 24464615
Septins are filament-forming GTP-binding proteins involved in important cellular events, such as cytokinesis, barrier formation, and membrane remodeling. Here, we present two crystal structures of the GTPase domain of a...
9.
Kalbitzer H, Rosnizeck I, Munte C, Narayanan S, Kropf V, Spoerner M
Angew Chem Int Ed Engl
. 2013 Nov;
52(52):14242-6.
PMID: 24218090
No abstract available.
10.
Miertzschke M, Koerner C, Spoerner M, Wittinghofer A
Biochem J
. 2013 Oct;
457(2):301-11.
PMID: 24168557
Ciliopathies are human diseases arising from defects in primary or motile cilia. The small G-protein Arl13B (ADP-ribosylation factor-like 13B) localizes to microtubule doublets of the ciliary axoneme and is mutated...