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Michael S Kobor

Explore the profile of Michael S Kobor including associated specialties, affiliations and a list of published articles. Areas
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Articles 253
Citations 9429
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Recent Articles
1.
Jones M, Konwar C, Asiimwe R, Dinh L, Razzaghian H, de Goede O, et al.
Commun Biol . 2025 Feb; 8(1):237. PMID: 39953282
Epigenetic modifications such as DNA methylation are both cell type and developmental age specific. Here, we show that the immunological maturation of blood cell types influences DNA methylation changes from...
2.
Brewis H, Stirling P, Kobor M
PLoS Genet . 2025 Jan; 21(1):e1011566. PMID: 39836664
Chromatin structure and DNA accessibility are partly modulated by the incorporation of histone variants. H2A.Z, encoded by the non-essential HTZ1 gene in S. cerevisiae, is an evolutionarily conserved H2A histone...
3.
Merrill S, Konwar C, Fatima F, Dever K, MacIsaac J, Letourneau N, et al.
Nat Commun . 2025 Jan; 16(1):609. PMID: 39800776
Cheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in...
4.
Chan M, Meijer M, Merrill S, Fu M, Lin D, MacIsaac J, et al.
bioRxiv . 2024 Nov; PMID: 39605421
Saliva is a widely used sample in epigenetic research with children due to its non-invasive nature. Since DNA methylation (DNAm) profile is cell type (CT) specific, salivary DNAm associations with...
5.
Lussier A, Schuurmans I, Grossbach A, Maclsaac J, Dever K, Koen N, et al.
Clin Epigenetics . 2024 Nov; 16(1):166. PMID: 39578866
DNA methylation (DNAm) is the most commonly measured epigenetic mechanism in human populations, with most studies using Illumina arrays to assess DNAm levels. In 2023, Illumina updated their DNAm arrays...
6.
Abrishamcar S, Zhuang B, Thomas M, Gladish N, MacIsaac J, Jones M, et al.
Transl Psychiatry . 2024 Oct; 14(1):445. PMID: 39438450
Maternal stress and depression during pregnancy and the first year of the infant's life affect a large percentage of mothers. Maternal stress and depression have been associated with adverse fetal...
7.
Hernandez Cordero A, Peters C, Li X, Xi Yang C, Ambalavanan A, MacIsaac J, et al.
iScience . 2024 Oct; 27(10):110934. PMID: 39391738
We hypothesized that increased cardiorespiratory fitness (CRF) slows down a person's aging, particularly in individuals with chronic airflow limitation (CAL). Participants aged ≥40 years ( = 78) had baseline blood...
8.
Wu R, Hamden J, Salehzadeh M, Li M, Poudel A, Schmidt K, et al.
PLoS One . 2024 Aug; 19(8):e0309478. PMID: 39197060
Steroid hormones are important modulators of many physiological processes, and measurements of steroids in blood, saliva, and urine matrices are widely used to assess endocrine pathologies and stress. However, these...
9.
England-Mason G, Merrill S, Liu J, Martin J, MacDonald A, Kinniburgh D, et al.
Epigenomes . 2024 Aug; 8(3). PMID: 39189257
We examined whether prenatal exposure to two classes of endocrine-disrupting chemicals (EDCs) was associated with infant epigenetic age acceleration (EAA), a DNA methylation biomarker of aging. Participants included 224 maternal-infant...
10.
Sullivan A, Merrill S, Konwar C, Coccia M, Rivera L, MacIsaac J, et al.
Psychol Sci . 2024 Aug; 35(9):1062-1073. PMID: 39141017
Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation...