Michael R Stallcup
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Explore the profile of Michael R Stallcup including associated specialties, affiliations and a list of published articles.
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70
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3467
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Recent Articles
1.
Lee R, Chang M, Yiv N, Tsay A, Tian S, Li D, et al.
Nat Commun
. 2023 May;
14(1):3143.
PMID: 37253782
The classical dogma of glucocorticoid-induced insulin resistance is that it is caused by the transcriptional activation of hepatic gluconeogenic and insulin resistance genes by the glucocorticoid receptor (GR). Here, we...
2.
Malbeteau L, Pham H, Eve L, Stallcup M, Poulard C, Le Romancer M
Endocr Rev
. 2021 May;
43(1):160-197.
PMID: 33955470
Steroid receptors (SRs) are members of the nuclear hormonal receptor family, many of which are transcription factors regulated by ligand binding. SRs regulate various human physiological functions essential for maintenance...
3.
Stallcup M, Poulard C
Trends Biochem Sci
. 2020 May;
45(6):497-510.
PMID: 32413325
The actions of transcriptional coregulators are highly gene-specific, that is, each coregulator is required only for a subset of the genes regulated by a specific transcription factor. These coregulator-specific gene...
4.
Poulard C, Kim H, Fang M, Kruth K, Gagnieux C, Gerke D, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(8):3052-3061.
PMID: 30733284
Glucocorticoids (GCs) are used in combination chemotherapies as front-line treatment for B cell acute lymphoblastic leukemia (B-ALL). Although effective, many patients relapse and become resistant to chemotherapy and GCs in...
5.
Poulard C, Baulu E, Lee B, Pufall M, Stallcup M
Cell Death Dis
. 2018 Oct;
9(10):1038.
PMID: 30305606
Synthetic glucocorticoids (GCs) are used to treat lymphoid cancers, but many patients develop resistance to treatment, especially to GC. By identifying genes that influence sensitivity to GC-induced cell death, we...
6.
Jin M, Kim Y, Jin H, Kang H, Lee E, Stallcup M, et al.
Int J Cancer
. 2018 Sep;
143(11):2871-2883.
PMID: 30191958
The histone H3 lysine 4-specific methyltransferase SETD1A is associated with transcription activation and is considered a key epigenetic regulator that modulates the cell cycle and metastasis in triple-negative breast cancer...
7.
Lee B, Stallcup M
PLoS One
. 2018 May;
13(5):e0196965.
PMID: 29738565
The glucocorticoid receptor (GR) regulates genes in many physiological pathways by binding to enhancer and silencer elements of target genes, where it recruits coregulator proteins that remodel chromatin and regulate...
8.
Poulard C, Bittencourt D, Wu D, Hu Y, Gerke D, Stallcup M
EMBO Rep
. 2017 Jun;
18(8):1442-1459.
PMID: 28615290
Like many transcription regulators, histone methyltransferases G9a and G9a-like protein (GLP) can act gene-specifically as coregulators, but mechanisms controlling this specificity are mostly unknown. We show that adjacent post-translational methylation...
9.
Lee B, Stallcup M
J Biol Chem
. 2017 Apr;
292(22):9320-9334.
PMID: 28381557
The steroid hormone-activated glucocorticoid receptor (GR) regulates cellular stress pathways by binding to genomic regulatory elements of target genes and recruiting coregulator proteins to remodel chromatin and regulate transcription complex...
10.
Wu D, Bittencourt D, Stallcup M, Siegmund K
Front Genet
. 2015 May;
6:169.
PMID: 25972895
ChIP seq is a widely used assay to measure genome-wide protein binding. The decrease in costs associated with sequencing has led to a rise in the number of studies that...