Michael R Dufault
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Explore the profile of Michael R Dufault including associated specialties, affiliations and a list of published articles.
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14
Citations
297
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Recent Articles
1.
McInnis J, Sood D, Guo L, Dufault M, Garcia M, Passaro R, et al.
Commun Biol
. 2024 Nov;
7(1):1597.
PMID: 39616264
Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several neurologic diseases. Ceramides are often...
2.
Gruber R, Wirak G, Blazier A, Lee L, Dufault M, Hagan N, et al.
Nat Commun
. 2024 Nov;
15(1):10116.
PMID: 39578444
Neuroinflammation in the central nervous system (CNS), driven largely by resident phagocytes, has been proposed as a significant contributor to disability accumulation in multiple sclerosis (MS) but has not been...
3.
Anding A, Kinton S, Baranowski K, Brezzani A, De Busser H, Dufault M, et al.
J Pharmacol Exp Ther
. 2023 Sep;
387(2):188-203.
PMID: 37679046
Pompe disease is a rare glycogen storage disorder caused by a deficiency in the lysosomal enzyme acid -glucosidase, which leads to muscle weakness, cardiac and respiratory failure, and early mortality....
4.
Kinton S, Dufault M, Zhang M, George K
Mol Genet Metab
. 2023 Feb;
138(3):107526.
PMID: 36774918
Pompe disease is a rare lysosomal storage disorder arising from recessive mutations in the acid α-glucosidase gene and resulting in the accumulation of glycogen, particularly in the cardiac and skeletal...
5.
Dumont M, Weber-Lassalle N, Joly-Beauparlant C, Ernst C, Droit A, Feng B, et al.
Cancers (Basel)
. 2022 Jul;
14(14).
PMID: 35884425
Rare variants in at least 10 genes, including BRCA1, BRCA2, PALB2, ATM, and CHEK2, are associated with increased risk of breast cancer; however, these variants, in combination with common variants...
6.
Southey M, Park D, Nguyen-Dumont T, Campbell I, Thompson E, Trainer A, et al.
Breast Cancer Res
. 2013 Jul;
15(3):402.
PMID: 23809231
Linkage analysis, positional cloning, candidate gene mutation scanning and genome-wide association study approaches have all contributed significantly to our understanding of the underlying genetic architecture of breast cancer. Taken together,...
7.
Chai L, McLaren R, Byrne A, Chuang W, Huang Y, Dufault M, et al.
Int J Oncol
. 2010 Dec;
38(3):701-11.
PMID: 21186402
Glucosylceramide synthase (GCS) is a key enzyme engaged in the biosynthesis of glycosphingolipids and in regulating ceramide metabolism. Studies exploring alterations in GCS activity suggest that the glycolase may have...
8.
Byrne A, McLaren R, Mason P, Chai L, Dufault M, Huang Y, et al.
Exp Cell Res
. 2009 Sep;
316(2):258-71.
PMID: 19732767
The PSMD14 (POH1, also known as Rpn11/MPR1/S13/CepP1) protein within the 19S complex (19S cap; PA700) is responsible for substrate deubiquitination during proteasomal degradation. The role of PSMD14 in cell proliferation...
9.
Gibbings J, Cook B, Dufault M, Madden S, Khuri S, Turnbull C, et al.
Plant Biotechnol J
. 2006 Dec;
1(4):271-85.
PMID: 17163904
We have compiled two comprehensive gene expression profiles from mature leaf and immature seed tissue of rice (Oryza sativa ssp. japonica cultivar Nipponbare) using Serial Analysis of Gene Expression (SAGE)...
10.
Morgenbesser S, McLaren R, Richards B, Zhang M, Akmaev V, Winter S, et al.
Prostate
. 2006 Oct;
67(1):83-106.
PMID: 17013881
Background: A major focus of prostate cancer research has been to identify genes that are deregulated during tumor progression, potentially providing diagnostic markers and therapeutic targets. Methods: We have employed...