Michael R Copley
Overview
Explore the profile of Michael R Copley including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
864
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Recent Articles
1.
Wohrer S, Knapp D, Copley M, Benz C, Kent D, Rowe K, et al.
Cell Rep
. 2014 Jun;
7(6):1956-67.
PMID: 24910437
Hematopoietic stem cells (HSCs) are identified by their ability to sustain prolonged blood cell production in vivo, although recent evidence suggests that durable self-renewal (DSR) is shared by HSC subtypes...
2.
Copley M, Eaves C
Exp Mol Med
. 2013 Nov;
45:e55.
PMID: 24232254
Hematopoietic stem cells (HSCs) comprise a rare population of cells that can regenerate and maintain lifelong blood cell production. This functionality is achieved through their ability to undergo many divisions...
3.
Copley M, Babovic S, Benz C, Knapp D, Beer P, Kent D, et al.
Nat Cell Biol
. 2013 Jul;
15(8):916-25.
PMID: 23811688
Mouse haematopoietic stem cells (HSCs) undergo a postnatal transition in several properties, including a marked reduction in their self-renewal activity. We now show that the developmentally timed change in this...
4.
Copley M, Beer P, Eaves C
Cell Stem Cell
. 2012 Jun;
10(6):690-697.
PMID: 22704509
Over the past 10 years, increasing evidence has accumulated that heterogeneity is a feature of hematopoietic stem cell (HSC) proliferation, self-renewal, and differentiation based on examination of these properties at...
5.
Benz C, Copley M, Kent D, Wohrer S, Cortes A, Aghaeepour N, et al.
Cell Stem Cell
. 2012 Mar;
10(3):273-83.
PMID: 22385655
Adult hematopoietic stem cells (HSCs) with serially transplantable activity comprise two subtypes. One shows a balanced output of mature lymphoid and myeloid cells; the other appears selectively lymphoid deficient. We...
6.
Lecault V, VanInsberghe M, Sekulovic S, Knapp D, Wohrer S, Bowden W, et al.
Nat Methods
. 2011 May;
8(7):581-6.
PMID: 21602799
Heterogeneity in cell populations poses a major obstacle to understanding complex biological processes. Here we present a microfluidic platform containing thousands of nanoliter-scale chambers suitable for live-cell imaging studies of...
7.
Kent D, Copley M, Benz C, Wohrer S, Dykstra B, Ma E, et al.
Blood
. 2009 Apr;
113(25):6342-50.
PMID: 19377048
Hematopoietic stem cells (HSCs) are generally defined by their dual properties of pluripotency and extensive self-renewal capacity. However, a lack of experimental clarity as to what constitutes extensive self-renewal capacity...
8.
Bowie M, Kent D, Copley M, Eaves C
Blood
. 2007 Mar;
109(11):5043-8.
PMID: 17327414
Fetal hematopoietic stem cells (HSCs) regenerate daughter HSCs in irradiated recipients more rapidly than do adult HSCs. However, both types of HSCs divide in vitro with the same cell-cycle transit...