Michael P Gallagher
Overview
Explore the profile of Michael P Gallagher including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
342
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Recent Articles
1.
Gallagher M, Conley J, Vangala P, Garber M, Reboldi A, Berg L
Proc Natl Acad Sci U S A
. 2021 Aug;
118(35).
PMID: 34452995
The strength of peptide:MHC interactions with the T cell receptor (TCR) is correlated with the time to first cell division, the relative scale of the effector cell response, and the...
2.
Conley J, Gallagher M, Rao A, Berg L
J Immunol
. 2020 Jun;
205(2):335-345.
PMID: 32493815
TCR signal strength is critical for CD8 T cell clonal expansion after Ag stimulation. Levels of the transcription factor IRF4 control the magnitude of this process through the induction of...
3.
Gallagher M, Conley J, Berg L
Immunohorizons
. 2018 Sep;
2(7):208-215.
PMID: 30221251
Circulating naive T cells exist in a quiescent state. After TCR contact with the cognate peptide presented by APCs in secondary lymphoid structures, T cells undergo a period of rapid...
4.
Tong P, Granato A, Zuo T, Chaudhary N, Zuiani A, Han S, et al.
Proc Natl Acad Sci U S A
. 2017 Sep;
114(40):E8411-E8420.
PMID: 28923960
Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE) are generated as secreted/soluble antibodies (sIg) or as membrane-bound (mIg) B cell receptors (BCRs) through alternative RNA splicing. IgH isotype...
5.
6.
Conley J, Gallagher M, Berg L
Front Immunol
. 2016 Mar;
7:76.
PMID: 26973653
Signaling downstream of the T cell receptor (TCR) is directly regulated by the dose and affinity of peptide antigen. The strength of TCR signaling drives a multitude of T cell...
7.
Gallagher M, Shrestha A, Magee J, Wesemann D
J Vis Exp
. 2014 Dec;
(94).
PMID: 25490087
B lymphocyte immunoglobulin heavy chain (IgH) class switch recombination (CSR) is a process wherein initially expressed IgM switches to other IgH isotypes, such as IgA, IgE and IgG. Measurement of...
8.
Wesemann D, Portuguese A, Meyers R, Gallagher M, Cluff-Jones K, Magee J, et al.
Nature
. 2013 Aug;
501(7465):112-5.
PMID: 23965619
The RAG1/RAG2 endonuclease (RAG) initiates the V(D)J recombination reaction that assembles immunoglobulin heavy (IgH) and light (IgL) chain variable region exons from germline gene segments to generate primary antibody repertoires....
9.
Wesemann D, Portuguese A, Magee J, Gallagher M, Zhou X, Panchakshari R, et al.
Proc Natl Acad Sci U S A
. 2012 Aug;
109(34):13745-50.
PMID: 22869756
Induced pluripotent stem cells (iPSCs) can be formed from somatic cells by a defined set of genetic factors; however, aberrant epigenetic silencing of the imprinted Dlk1-Dio3 gene cluster often hinders...
10.
Wesemann D, Magee J, Boboila C, Calado D, Gallagher M, Portuguese A, et al.
J Exp Med
. 2011 Dec;
208(13):2733-46.
PMID: 22143888
Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expressed Cμ (IgM) constant regions (C(H)) exons with downstream C(H) exons. Stimulation of B cells with anti-CD40 plus interleukin-4 induces CSR...