Michael P Brugts
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Explore the profile of Michael P Brugts including associated specialties, affiliations and a list of published articles.
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12
Citations
132
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Recent Articles
1.
Aanstoot H, Varkevisser R, Mul D, Dekker P, Birnie E, Boesten L, et al.
BMJ Open
. 2024 Jun;
14(6):e082453.
PMID: 38904129
Purpose: The 'Biomarkers of heterogeneity in type 1 diabetes' study cohort was set up to identify genetic, physiological and psychosocial factors explaining the observed heterogeneity in disease progression and the...
2.
Janssen J, Varewijck A, Brugts M
Growth Horm IGF Res
. 2019 Sep;
48-49:16-28.
PMID: 31493625
Determination of true IGF-I bioactivity in serum and other biological fluids is still a substantial challenge. The IGF-IR Kinase Receptor Activation assay (IGF-IR KIRA assay) is a novel tool to...
3.
Galle S, van der Spek A, Drent M, Brugts M, Scherder E, Janssen J, et al.
Front Aging Neurosci
. 2019 Feb;
11:20.
PMID: 30809143
: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated with dementia and Alzheimer's disease (AD). Studies on the association between IGF-I levels and dementia risk have been...
4.
van Adrichem R, de Herder W, Kamp K, Brugts M, de Krijger R, Sprij-Mooij D, et al.
Neuroendocrinology
. 2016 Feb;
103(6):815-25.
PMID: 26836610
Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) express insulin-like growth factor (IGF)-related factors [IGF1, IGF2; insulin receptor (IR)-A, IR-B; IGF-binding protein (IGFBP) 1-3] as well as somatostatin (SSTRs) and dopamine D2 receptors...
5.
Kascakova S, Hofland L, de Bruijn H, Ye Y, Achilefu S, van der Wansem K, et al.
PLoS One
. 2014 Aug;
9(8):e104448.
PMID: 25111655
Photodynamic therapy (PDT) is an established treatment modality, used mainly for anticancer therapy that relies on the interaction of photosensitizer, light and oxygen. For the treatment of pathologies in certain...
6.
de Bruijn R, Janssen J, Brugts M, Van Duijn C, Hofman A, Koudstaal P, et al.
J Alzheimers Dis
. 2014 May;
42(1):137-42.
PMID: 24820016
Background: Insulin-like growth factor-I (IGF-I) is a pleiotropic hormone. Several studies have related IGF-I levels to dementia, but evidence remains inconclusive. IGF-I receptor stimulating activity is a more direct measure...
7.
Vitale G, Brugts M, Ogliari G, Castaldi D, Fatti L, Varewijck A, et al.
Aging (Albany NY)
. 2012 Sep;
4(9):580-9.
PMID: 22983440
Unlabelled: Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate...
8.
Varewijck A, Brugts M, Frystyk J, Goudzwaard J, Uitterlinden P, Waaijers A, et al.
Mol Cell Endocrinol
. 2012 Sep;
365(1):17-24.
PMID: 22982059
Background: Only a fraction of circulating insulin-like activity is due to insulin itself. The aim of this study was to determine total serum insulin-like activity mediated via the insulin receptor...
9.
van den Beld A, Blum W, Brugts M, Janssen J, Grobbee D, Lamberts S
Eur J Endocrinol
. 2012 May;
167(1):111-7.
PMID: 22555360
Objective: Serum IGF-binding protein 2 (IGFBP2) concentrations are reduced in obese humans and increase after a prolonged period of fasting. We investigated the association between IGFBP2 levels and mortality together...
10.
Brugts M, Van Duijn C, Hofland L, Witteman J, Lamberts S, Janssen J
Diabetes
. 2010 Jan;
59(2):505-8.
PMID: 20103714
Objective: There is a complex relationship between IGF-I, IGF binding proteins, growth hormone, and insulin. The IGF-I kinase receptor activation assay (KIRA) is a novel method for measuring IGF-I bioactivity...