Joseph A M J L Janssen
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Explore the profile of Joseph A M J L Janssen including associated specialties, affiliations and a list of published articles.
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1012
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Recent Articles
1.
Janssen J
Int J Mol Sci
. 2025 Jan;
25(24.
PMID: 39769002
Consuming a "modern" Western diet and overnutrition may increase insulin secretion. Additionally, nutrition-mediated hyperinsulinemia is a major driver of ectopic fat deposition. The global prevalence of metabolic syndrome is high...
2.
3.
Janssen J
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791525
The worldwide incidence of prediabetes/type 2 has continued to rise the last 40 years. In the same period, the mean daily energy intake has increased, and the quality of food...
4.
Janssen J
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36901984
The metabolic syndrome is a cluster of overlapping conditions resulting in an increased incidence of type 2 diabetes, cardiovascular disease, and cancer. In the last few decades, prevalence of the...
5.
Janssen J
Int J Mol Sci
. 2022 Jul;
23(15).
PMID: 35897752
Recent data suggests that (pre)diabetes onset is preceded by a period of hyperinsulinemia. Consumption of the "modern" Western diet, over-nutrition, genetic background, decreased hepatic insulin clearance, and fetal/metabolic programming may...
6.
Girnita L, Smith T, Janssen J
J Clin Endocrinol Metab
. 2022 Feb;
107(Suppl_1):S1-S12.
PMID: 35167695
Context: Thyroid eye disease (TED) is a complex autoimmune disease process. Orbital fibroblasts represent the central orbital immune target. Involvement of the TSH receptor (TSHR) in TED is not fully...
7.
Janssen J
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34360563
For many years, the dogma has been that insulin resistance precedes the development of hyperinsulinemia. However, recent data suggest a reverse order and place hyperinsulinemia mechanistically upstream of insulin resistance....
8.
Berk S, Janssen J, Van Koetsveld P, Dogan F, Degerli N, Ozcan S, et al.
Front Oncol
. 2021 Jul;
11:645732.
PMID: 34290976
There are only a few experimental studies which have investigated effects of glucose alone, and glucose in combination with insulin/insulin-like growth factors (IGF) on the growth of colon cancer. In...
9.
Janssen J, Smith T
Cells
. 2021 Mar;
10(2).
PMID: 33673340
Complex immunological mechanisms underlie the pathogenesis of thyroid-associated ophthalmopathy (TAO). Historical models of Graves' disease and TAO have focused almost entirely on autoimmune reactivity directed against the thyrotropin receptor (TSHR)....
10.
van Santen S, Olsson D, Hammarstrand C, Wijnen M, Fiocco M, van den Heuvel-Eibrink M, et al.
J Clin Endocrinol Metab
. 2020 Sep;
105(12).
PMID: 32869850
Context: Patients with craniopharyngioma suffer from obesity and impaired bone health. Little is known about longitudinal changes in body composition and bone mineral density (BMD). Objective: To describe body composition...