Michael Melcher
Overview
Explore the profile of Michael Melcher including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
353
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Recent Articles
1.
Hodgskiss L, Melcher M, Kerou M, Chen W, Ponce-Toledo R, Savvides S, et al.
ISME J
. 2023 Apr;
17(6):947.
PMID: 37117330
No abstract available.
2.
Melcher M, Hodgskiss L, Mardini M, Schleper C, Rittmann S
Front Microbiol
. 2023 Mar;
14:1076342.
PMID: 36876066
Microbial ammonia oxidation is the first and usually rate limiting step in nitrification and is therefore an important step in the global nitrogen cycle. Ammonia-oxidizing archaea (AOA) play an important...
3.
Hodgskiss L, Melcher M, Kerou M, Chen W, Ponce-Toledo R, Savvides S, et al.
ISME J
. 2023 Jan;
17(4):588-599.
PMID: 36721060
Ammonia oxidation, as the first step of nitrification, constitutes a critical process in the global nitrogen cycle. However, fundamental knowledge of its key enzyme, the copper-dependent ammonia monooxygenase, is lacking,...
4.
Christler A, Scharl T, Sauer D, Koppl J, Tscheliessnig A, Toy C, et al.
Biotechnol Bioeng
. 2021 Jun;
118(10):3941-3952.
PMID: 34170524
Technological developments require the transfer to their location of application to make use of them. We describe the transfer of a real-time monitoring system for lab-scale preparative chromatography to two...
5.
Szeliova D, Iurashev D, Ruckerbauer D, Koellensperger G, Borth N, Melcher M, et al.
Biotechnol J
. 2020 Dec;
16(4):e2000320.
PMID: 33340257
Chinese hamster ovary (CHO) cells are the most popular mammalian cell factories for the production of glycosylated biopharmaceuticals. To further increase titer and productivity and ensure product quality, rational system-level...
6.
Dhiman H, Campbell M, Melcher M, Smith K, Borth N
Comput Struct Biotechnol J
. 2020 Dec;
18:3632-3648.
PMID: 33304461
Chinese Hamster Ovary (CHO) cell lines are considered to be the preferred platform for the production of biotherapeutics, but issues related to expression instability remain unresolved. In this study, we...
7.
Mooshammer M, Alves R, Bayer B, Melcher M, Stieglmeier M, Jochum L, et al.
Front Microbiol
. 2020 Aug;
11:1710.
PMID: 32849360
The naturally occurring nitrogen (N) isotopes, N and N, exhibit different reaction rates during many microbial N transformation processes, which results in N isotope fractionation. Such isotope effects are critical...
8.
Bayer B, von Stosch M, Melcher M, Duerkop M, Striedner G
Eng Life Sci
. 2020 Jul;
20(1-2):26-35.
PMID: 32625044
In bioprocesses, specific process responses such as the biomass cannot typically be measured directly on-line, since analytical sampling is associated with unavoidable time delays. Accessing those responses in real-time is...
9.
Klanert G, Fernandez D, Weinguny M, Eisenhut P, Buhler E, Melcher M, et al.
Sci Rep
. 2019 Jun;
9(1):8689.
PMID: 31213643
High-throughput siRNA screens were only recently applied to cell factories to identify novel engineering targets which are able to boost cells towards desired phenotypes. While siRNA libraries exist for model...
10.
Walch N, Scharl T, Felfoldi E, Sauer D, Melcher M, Leisch F, et al.
Biotechnol J
. 2019 Apr;
14(7):e1800521.
PMID: 30945440
Regulatory recommendations for quality by design instead of quality by testing raise increasing interest in new sensor technologies. An online monitoring system for downstream processes is developed, which is based...