Michael Meanwell
Overview
Explore the profile of Michael Meanwell including associated specialties, affiliations and a list of published articles.
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14
Citations
117
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Recent Articles
1.
Smith B, Truax N, Pollatos A, Meanwell M, Bedekar P, Garrido-Castro A, et al.
Angew Chem Int Ed Engl
. 2024 Feb;
63(19):e202401107.
PMID: 38358802
The first total synthesis of dragocins A-C, remarkable natural products containing an unusual C4' oxidized ribose architecture bridged by a polyhydroxylated pyrrolidine, is presented through a route featuring a number...
2.
Meanwell M, Fehr G, Ren W, Adluri B, Rose V, Lehmann J, et al.
Commun Chem
. 2023 Jan;
4(1):96.
PMID: 36697548
Glycomimetics are structural mimics of naturally occurring carbohydrates and represent important therapeutic leads in several disease treatments. However, the structural and stereochemical complexity inherent to glycomimetics often challenges medicinal chemistry...
3.
Davison E, Petrone D, Meanwell M, Nodwell M, Silverman S, Campeau L, et al.
Nat Protoc
. 2022 Jul;
17(9):2008-2024.
PMID: 35788720
Nucleoside analogs are valuable commodities in the development of antisense oligonucleotides or as stand-alone antiviral and anticancer therapies. Syntheses of nucleoside analogs are typically challenged by a reliance on chiral...
4.
Saito M, Kawamata Y, Meanwell M, Navratil R, Chiodi D, Carlson E, et al.
J Am Chem Soc
. 2021 May;
143(20):7859-7867.
PMID: 33983721
The site-specific oxidation of strong C(sp)-H bonds is of uncontested utility in organic synthesis. From simplifying access to metabolites and late-stage diversification of lead compounds to truncating retrosynthetic plans, there...
5.
Meanwell M, Silverman S, Lehmann J, Adluri B, Wang Y, Cohen R, et al.
Science
. 2020 Aug;
369(6504):725-730.
PMID: 32764073
Nucleoside analogs are commonly used in the treatment of cancer and viral infections. Their syntheses benefit from decades of research but are often protracted, unamenable to diversification, and reliant on...
6.
Newton J, Jelier B, Meanwell M, Martin R, Britton R, Friesen C
Org Lett
. 2020 Feb;
22(5):1785-1790.
PMID: 32053386
The reaction of nucleophilic tertiary amines with trifluoromethyl and pentafluoroethyl methyl ethers provides quaternary ammonium trifluoromethoxide (NROCF) and pentafluoroethoxide (NROCFCF) salts, respectively, in good yields. The new trifluoromethoxide salts disclosed...
7.
Ren W, Pengelly R, Farren-Dai M, Shamsi Kazem Abadi S, Oehler V, Akintola O, et al.
Nat Commun
. 2018 Sep;
9(1):3700.
PMID: 30194298
In the originally published version of this Article, the affiliation details for Tracey M. Gloster were incorrectly given as 'Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University...
8.
Meanwell M, Lehmann J, Eichenberger M, Martin R, Britton R
Chem Commun (Camb)
. 2018 Aug;
54(71):9985-9988.
PMID: 30123905
Acyl fluorides are versatile acylating agents owing to their unique stability. Their synthesis, however, can present challenges and is typically accomplished through deoxyfluorination of carboxylic acids. Here, we demonstrate that...
9.
Ren W, Pengelly R, Farren-Dai M, Shamsi Kazem Abadi S, Oehler V, Akintola O, et al.
Nat Commun
. 2018 Aug;
9(1):3243.
PMID: 30104598
Mechanism-based glycoside hydrolase inhibitors are carbohydrate analogs that mimic the natural substrate's structure. Their covalent bond formation with the glycoside hydrolase makes these compounds excellent tools for chemical biology and...
10.
Meanwell M, Adluri B, Yuan Z, Newton J, Prevost P, Nodwell M, et al.
Chem Sci
. 2018 Aug;
9(25):5608-5613.
PMID: 30061993
Functionalization of heterocyclic scaffolds with mono- or difluoroalkyl groups provides unique opportunities to modulate drug p, influence potency and membrane permeability, and attenuate metabolism. While advances in the addition of...