Michael Marconi
Overview
Explore the profile of Michael Marconi including associated specialties, affiliations and a list of published articles.
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9
Citations
214
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Recent Articles
1.
Larson K, Martens L, Marconi M, DeJesus C, Bruhn S, Miller T, et al.
J Neuroinflammation
. 2024 Jan;
21(1):37.
PMID: 38297405
Neuroinflammation is a key driver of neurodegenerative disease, however the tools available to model this disease biology at the systems level are lacking. We describe a translational drug discovery platform...
2.
Seneviratne U, Huang Z, Am Ende C, Butler T, Cleary L, Dresselhaus E, et al.
Cell Chem Biol
. 2020 Sep;
28(2):148-157.e7.
PMID: 32997975
Utilizing a phenotypic screen, we identified chemical matter that increased astrocytic apoE secretion in vitro. We designed a clickable photoaffinity probe based on a pyrrolidine lead compound and carried out...
3.
Wager T, Galatsis P, Chandrasekaran R, Butler T, Li J, Zhang L, et al.
ACS Chem Neurosci
. 2017 Jun;
8(9):1995-2004.
PMID: 28609096
To enable the clinical development of our CNS casein kinase 1 delta/epsilon (CK1δ/ε) inhibitor project, we investigated the possibility of developing a CNS positron emission tomography (PET) radioligand. For this...
4.
Wager T, Chandrasekaran R, Bradley J, Rubitski D, Berke H, Mente S, et al.
ACS Chem Neurosci
. 2014 Oct;
5(12):1253-65.
PMID: 25299732
Casein kinase 1 delta (CK1δ) and casein kinase 1 epsilon (CK1ε) inhibitors are potential therapeutic agents for a range of psychiatric disorders. The feasibility of developing a CNS kinase inhibitor...
5.
Mente S, Arnold E, Butler T, Chakrapani S, Chandrasekaran R, Cherry K, et al.
J Med Chem
. 2013 Aug;
56(17):6819-28.
PMID: 23919824
Casein kinase 1δ (CK1δ) and 1ε (CK1ε) are believed to be necessary enzymes for the regulation of circadian rhythms in all mammals. On the basis of our previously published work...
6.
Teng Y, Benn S, Kalkanis S, Shefner J, Onario R, Cheng B, et al.
Sci Transl Med
. 2012 Dec;
4(165):165ra164.
PMID: 23253611
Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by the unremitting degeneration of motor neurons. Multiple processes involving motor neurons and other cell types have been implicated in its...
7.
High throughput object-based image analysis of β-amyloid plaques in human and transgenic mouse brain
Samaroo H, Opsahl A, Schreiber J, ONeill S, Marconi M, Qian J, et al.
J Neurosci Methods
. 2011 Oct;
204(1):179-188.
PMID: 22019329
Advances in imaging technology have enabled automated approaches for quantitative image analysis. In this study, a high content object based image analysis method was developed for quantification of β-amyloid (Aβ)...
8.
Walton K, Fisher K, Rubitski D, Marconi M, Meng Q, Sladek M, et al.
J Pharmacol Exp Ther
. 2009 May;
330(2):430-9.
PMID: 19458106
The circadian clock links our daily cycles of sleep and activity to the external environment. Deregulation of the clock is implicated in a number of human disorders, including depression, seasonal...
9.
Lanz T, Salatto C, Semproni A, Marconi M, Brown T, Richter K, et al.
Biochem Pharmacol
. 2007 Dec;
75(5):1093-103.
PMID: 18076866
Increasing beta-amyloid (Abeta) clearance may alter the course of Alzheimer's disease progression and attenuate amyloid plaque pathology. Insulin-like growth factor I (IGF-1) augmentation has been suggested to increase Abeta clearance...