Michael M Kaminski
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Explore the profile of Michael M Kaminski including associated specialties, affiliations and a list of published articles.
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19
Citations
584
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Recent Articles
1.
Ibel A, Bhardwaj R, Yilmaz D, Kong S, Wendlinger S, Papaioannou D, et al.
bioRxiv
. 2025 Feb;
PMID: 39975003
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disorder, affecting over 10 million individuals worldwide. Cystic expansion typically progresses to kidney failure and also involves the...
2.
Greensmith R, Lape I, Riella C, Schubert A, Metzger J, Dighe A, et al.
EMBO Mol Med
. 2024 Sep;
16(10):2619-2637.
PMID: 39271961
Detecting genetic variants enables risk factor identification, disease screening, and initiation of preventative therapeutics. However, current methods, relying on hybridization or sequencing, are unsuitable for point-of-care settings. In contrast, CRISPR-based-diagnostics...
3.
Ilia K, Shakiba N, Bingham T, Jones R, Kaminski M, Aravera E, et al.
Sci Adv
. 2023 Nov;
9(48):eadg8495.
PMID: 38019912
Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient, with heterogeneity among transcription factor (TF) trajectories driving divergent cell states. Nevertheless, the impact of TF dynamics on reprogramming...
4.
Ilia K, Shakiba N, Bingham T, Jones R, Kaminski M, Aravera E, et al.
bioRxiv
. 2023 Feb;
PMID: 36747813
Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient, with heterogeneity among transcription factor (TF) trajectories driving divergent cell states. Nevertheless, the impact of TF dynamics on reprogramming...
5.
Grand K, Stoltz M, Rizzo L, Rock R, Kaminski M, Salinas G, et al.
J Am Soc Nephrol
. 2022 Dec;
34(3):412-432.
PMID: 36522156
Significance Statement: Mutations in hepatocyte nuclear factor-1 β ( HNF1B ) are the most common monogenic causes of congenital renal malformations. HNF1B is necessary to directly reprogram fibroblasts to induced...
6.
Pichler R, Rizzo L, Trondle K, Buhler M, Brucker H, Muller A, et al.
Biomaterials
. 2022 Nov;
291:121910.
PMID: 36403325
Renal tubular cells frequently lose differentiation markers and physiological properties when propagated in conventional cell culture conditions. Embedding cells in 3D microenvironments or controlling their 3D assembly by bioprinting can...
7.
Broto M, Kaminski M, Adrianus C, Kim N, Greensmith R, Dissanayake-Perera S, et al.
Nat Nanotechnol
. 2022 Aug;
17(10):1120-1126.
PMID: 35927321
CRISPR-based diagnostics enable specific sensing of DNA and RNA biomarkers associated with human diseases. This is achieved through the binding of guide RNAs to a complementary sequence that activates Cas...
8.
Naert T, Cicek O, Ogar P, Burgi M, Shaidani N, Kaminski M, et al.
Development
. 2021 Nov;
148(21).
PMID: 34739029
Genome editing simplifies the generation of new animal models for congenital disorders. However, the detailed and unbiased phenotypic assessment of altered embryonic development remains a challenge. Here, we explore how...
9.
Kaminski M, Abudayyeh O, Gootenberg J, Zhang F, Collins J
Nat Biomed Eng
. 2021 Jul;
5(7):643-656.
PMID: 34272525
The accurate and timely diagnosis of disease is a prerequisite for efficient therapeutic intervention and epidemiological surveillance. Diagnostics based on the detection of nucleic acids are among the most sensitive...
10.
Klambt V, Werth M, Onuchic-Whitford A, Getwan M, Kitzler T, Buerger F, et al.
Nephrol Dial Transplant
. 2020 Oct;
36(2):237-246.
PMID: 33097957
Background: An underlying monogenic cause of early-onset chronic kidney disease (CKD) can be detected in ∼20% of individuals. For many etiologies of CKD manifesting before 25 years of age, >200...