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Michael M Cyr

Explore the profile of Michael M Cyr including associated specialties, affiliations and a list of published articles. Areas
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Reece P, Baatjes A, Cyr M, Sehmi R, Denburg J
Immunology . 2013 Jan; 139(2):256-64. PMID: 23347362
Eosinophils are multi-functional leucocytes that play a role in inflammatory processes including allergy and infection. Although bone marrow (BM) inflammatory cells are the main source of eosinophil-basophil (Eo/B) differentiation-inducing cytokines,...
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Cyr M, Baatjes A, Dorman S, Crawford L, Sehmi R, Foley R, et al.
Open Respir Med J . 2009 Apr; 2:60-6. PMID: 19343093
Unlabelled: IL-5 is the primary cytokine that stimulates the production and survival of eosinophils and basophils from progenitor cells. The inhaled glucocorticoid, budesonide, has been shown to exert a therapeutic...
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Cyr M, Hayes L, Crawford L, Baatjes A, Keith P, Denburg J
Int Arch Allergy Immunol . 2005 Oct; 138(3):209-16. PMID: 16210859
Background: Eosinophil/basophil (Eo/B) progenitors fluctuate in the peripheral circulation during seasonal allergen exposure in atopic subjects. Several drugs have been shown to modulate Eo/B progenitor levels in the peripheral blood...
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Li J, Saito H, Crawford L, Inman M, Cyr M, Denburg J
Immunology . 2005 Feb; 114(3):386-96. PMID: 15720440
Eosinophil recruitment to the airways, including involvement of haemopoietic eosinophil-basophil progenitors (Eo/B-CFU), is primarily regulated by interleukin-5 (IL-5) and eotaxin. In this study, we investigated the haemopoietic mechanisms in upper...
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Denburg J, Hatfield H, Cyr M, Hayes L, Holt P, Sehmi R, et al.
Pediatr Res . 2004 Dec; 57(2):276-81. PMID: 15585690
Dietary n-3 polyunsaturated fatty acids (PUFA) may represent a mode of allergy prevention. Cord blood (CB) CD34+ hemopoietic progenitors are altered in infants at risk of atopy. We therefore studied...
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Saito H, Morikawa H, Howie K, Crawford L, Baatjes A, Denburg E, et al.
Immunology . 2004 Sep; 113(2):246-52. PMID: 15379985
The cysteinyl leukotrienes (cysLTs) are potent lipid mediators in allergic disease, acting through a receptor (cysLT1-R) which can be targeted in rhinitis and asthma. We investigated the effects of cysLT1-R...
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Baatjes A, Sehmi R, Saito H, Cyr M, Dorman S, Inman M, et al.
Pharmacol Ther . 2002 Aug; 95(1):63-72. PMID: 12163128
Marked eosinophilic infiltration is the typical inflammatory response associated with allergic inflammation. Previous research involving animal and human models has established a role for the eosinophil/basophil hematopoietic progenitor in a...