Lynn Crawford
Overview
Explore the profile of Lynn Crawford including associated specialties, affiliations and a list of published articles.
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10
Citations
88
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Recent Articles
1.
Aguet J, Fakhari N, Nguyen M, Mertens L, Szabo E, Ertl-Wagner B, et al.
J Physiol
. 2023 Feb;
601(6):1077-1093.
PMID: 36779673
Newborns with congenital heart disease undergoing cardiac surgery are at risk of neurodevelopmental impairment with limited understanding of the impact of intra-operative cardiopulmonary bypass (CPB), deep hypothermia and selective cerebral...
2.
Reece P, Thanendran A, Crawford L, Tulic M, Thabane L, Prescott S, et al.
J Allergy Clin Immunol
. 2010 Dec;
127(2):447-53.
PMID: 21167570
Background: Little is known regarding the prenatal determinants of innate immune responses in relation to infant allergic risk. Environmental exposures, including microbial stimuli, might predispose susceptible subjects to atopy and...
3.
Ellis A, Ackerman S, Crawford L, Du J, Bedi R, Denburg J
Pediatr Allergy Immunol
. 2010 Mar;
21(4 Pt 1):640-8.
PMID: 20337967
Eosinophil/basophil (Eo/B) progenitor phenotype and function in cord blood (CB) are associated with atopic risk at birth and infant clinical outcomes. Molecular analyses of eosinophil-basophil differentiation events could identify clinically...
4.
Cyr M, Baatjes A, Dorman S, Crawford L, Sehmi R, Foley R, et al.
Open Respir Med J
. 2009 Apr;
2:60-6.
PMID: 19343093
Unlabelled: IL-5 is the primary cytokine that stimulates the production and survival of eosinophils and basophils from progenitor cells. The inhaled glucocorticoid, budesonide, has been shown to exert a therapeutic...
5.
Roa J, Morikawa H, Crawford L, Baatjes A, Duong M, Denburg J
Immunology
. 2007 Jul;
122(3):438-44.
PMID: 17627772
The cysteinyl leukotrienes (cysLTs) are potent lipid mediators in allergic disease, acting through the receptors, cysLT1R and cysLTR2, and are produced by eosinophils derived from eosinophil/basophil (Eo/B) bone marrow (BM)...
6.
Cyr M, Hayes L, Crawford L, Baatjes A, Keith P, Denburg J
Int Arch Allergy Immunol
. 2005 Oct;
138(3):209-16.
PMID: 16210859
Background: Eosinophil/basophil (Eo/B) progenitors fluctuate in the peripheral circulation during seasonal allergen exposure in atopic subjects. Several drugs have been shown to modulate Eo/B progenitor levels in the peripheral blood...
7.
Li J, Saito H, Crawford L, Inman M, Cyr M, Denburg J
Immunology
. 2005 Feb;
114(3):386-96.
PMID: 15720440
Eosinophil recruitment to the airways, including involvement of haemopoietic eosinophil-basophil progenitors (Eo/B-CFU), is primarily regulated by interleukin-5 (IL-5) and eotaxin. In this study, we investigated the haemopoietic mechanisms in upper...
8.
Saito H, Morikawa H, Howie K, Crawford L, Baatjes A, Denburg E, et al.
Immunology
. 2004 Sep;
113(2):246-52.
PMID: 15379985
The cysteinyl leukotrienes (cysLTs) are potent lipid mediators in allergic disease, acting through a receptor (cysLT1-R) which can be targeted in rhinitis and asthma. We investigated the effects of cysLT1-R...
9.
Ramsay J, Simms R, Ferrell W, Crawford L, Greer I, Lumsden M, et al.
Diabetes Care
. 2003 Jan;
26(2):475-9.
PMID: 12547884
Objective: Pregnant women with type 1 diabetes have a substantially increased risk of vascular complications. Our aim was to study vascular function and metabolic and inflammatory risk factors during the...
10.
Saito H, Matsumoto K, Denburg A, Crawford L, Ellis R, Inman M, et al.
J Immunol
. 2002 Mar;
168(6):3017-23.
PMID: 11884474
Recent studies have demonstrated an important role for IL-5-dependent bone marrow eosinophil progenitors in allergic inflammation. However, studies using anti-IL-5 mAbs in human asthmatics have failed to suppress lower airway...