Michael L Neugent
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Explore the profile of Michael L Neugent including associated specialties, affiliations and a list of published articles.
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18
Citations
405
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Recent Articles
11.
Nguyen V, Khan F, Shipman B, Neugent M, Hulyalkar N, Cha N, et al.
Front Cell Infect Microbiol
. 2022 Jan;
11:803409.
PMID: 35047421
Glycosaminoglycans (GAGs) are linear polysaccharides and are among the primary components of mucosal surfaces in mammalian systems. The GAG layer lining the mucosal surface of the urinary tract is thought...
12.
Ebrahimzadeh T, Kuprasertkul A, Neugent M, Lutz K, Fuentes J, Gadhvi J, et al.
Life Sci Alliance
. 2021 May;
4(7).
PMID: 33958485
Urinary tract infection (UTI) is one of the most common adult bacterial infections and exhibits high recurrence rates, especially in postmenopausal women. Studies in mouse models suggest that cyclooxygenase-2 (COX-2)-mediated...
13.
Neugent M, Hulyalkar N, Nguyen V, Zimmern P, De Nisco N
mBio
. 2020 Apr;
11(2).
PMID: 32345639
Recent advances in the analysis of microbial communities colonizing the human body have identified a resident microbial community in the human urinary tract (UT). Compared to many other microbial niches,...
14.
Neugent M, Gadhvi J, Palmer K, Zimmern P, De Nisco N
J Vis Exp
. 2019 Nov;
(152).
PMID: 31680675
Visualization of the interaction of bacteria with host mucosal surfaces and tissues can provide valuable insight into mechanisms of pathogenesis. While visualization of bacterial pathogens in animal models of infection...
15.
Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka M, et al.
Nat Commun
. 2019 Jun;
10(1):2824.
PMID: 31249305
The fibrogenic response in tissue-resident fibroblasts is determined by the balance between activation and repression signals from the tissue microenvironment. While the molecular pathways by which transforming growth factor-1 (TGF-β1)...
16.
Do S, Jeong J, Lee S, Choi J, Hong M, Kang H, et al.
Ann Surg Oncol
. 2018 Aug;
25(11):3396-3403.
PMID: 30062472
Background: This study was conducted to investigate whether polymorphisms of glucose transporter 1 (GLUT1) gene are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical...
17.
Neugent M, Goodwin J, Sankaranarayanan I, Yetkin C, Hsieh M, Kim J
Biomol Ther (Seoul)
. 2017 Dec;
26(1):10-18.
PMID: 29212302
Tumors are dynamic metabolic systems which highly augmented metabolic fluxes and nutrient needs to support cellular proliferation and physiological function. For many years, a central hallmark of tumor metabolism has...
18.
Goodwin J, Neugent M, Kim J
Mol Cell Oncol
. 2017 Oct;
4(5):e1364211.
PMID: 29057314
Cancer cells consume high amounts of glucose for their cellular bioenergetic and anabolic requirements, relying on glucose to fuel their growth. We recently reported that lung squamous cell carcinoma, a...
19.
Goodwin J, Choi H, Hsieh M, Neugent M, Ahn J, Hayenga H, et al.
Am J Respir Cell Mol Biol
. 2017 Sep;
58(2):216-231.
PMID: 28915065
Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how various microenvironmental influences, such as hypoxia,...
20.
Goodwin J, Neugent M, Lee S, Choe J, Choi H, Jenkins D, et al.
Nat Commun
. 2017 May;
8:15503.
PMID: 28548087
Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. However, metabolic...