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Michael L Lehmann

Explore the profile of Michael L Lehmann including associated specialties, affiliations and a list of published articles. Areas
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Articles 26
Citations 863
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Recent Articles
1.
Kigar S, Lynall M, DePuyt A, Atkinson R, Sun V, Samuels J, et al.
bioRxiv . 2024 Sep; PMID: 39257811
Animal models of stress and stress-related disorders are also associated with blood neutrophilia. The mechanistic relevance of this to symptoms or behavior is unclear. We used cytometry, immunohistochemistry, whole tissue...
2.
Samuels J, Lotstein M, Lehmann M, Elkahloun A, Banerjee S, Herkenham M
J Neuroinflammation . 2023 Jun; 20(1):154. PMID: 37380974
Brain vascular integrity is critical for brain health, and its disruption is implicated in many brain pathologies, including psychiatric disorders. Brain-vascular barriers are a complex cellular landscape composed of endothelial,...
3.
Lehmann M, Samuels J, Kigar S, Poffenberger C, Lotstein M, Herkenham M
Brain Behav Immun . 2022 Jan; 101:346-358. PMID: 35063606
Immune surveillance of the brain plays an important role in health and disease. Peripheral leukocytes patrol blood-brain barrier interfaces, and after injury, monocytes cross the cerebrovasculature and follow a pattern...
4.
Duan K, Gu Q, Petralia R, Wang Y, Panja D, Liu X, et al.
Neuron . 2021 Oct; 109(23):3793-3809.e8. PMID: 34614419
Psychosocial stress is a common risk factor for anxiety disorders. The cellular mechanism for the anxiogenic effect of psychosocial stress is largely unclear. Here, we show that chronic social defeat...
5.
Lynall M, Kigar S, Lehmann M, DePuyt A, Tuong Z, Listwak S, et al.
Brain Behav Immun . 2021 Aug; 97:226-238. PMID: 34371135
There is increasing interest in how immune cells, including those within the meninges at the blood-brain interface, influence brain function and mood disorders, but little data on humoral immunity in...
6.
Lehmann M, Poffenberger C, Elkahloun A, Herkenham M
Brain Behav Immun . 2020 May; 88:735-747. PMID: 32413560
Psychological stress and affective disorders are clinically associated with hypertension and vascular disease, but the biological links between the conditions have not been fully explored. To examine this relationship, we...
7.
Shrestha S, Kim M, Eldridge M, Lehmann M, Frankland M, Liow J, et al.
J Neuroinflammation . 2020 May; 17(1):140. PMID: 32359360
Background: Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand...
8.
Kang B, Alvarado L, Kim T, Lehmann M, Cho H, He J, et al.
Mucosal Immunol . 2019 Nov; 13(2):216-229. PMID: 31772323
Mononuclear phagocytes are a heterogeneous population of leukocytes essential for immune homeostasis that develop tissue-specific functions due to unique transcriptional programs driven by local microenvironmental cues. Single cell RNA sequencing...
9.
Lehmann M, Weigel T, Poffenberger C, Herkenham M
J Neurosci . 2019 May; 39(28):5594-5605. PMID: 31085604
Chronic social defeat (CSD) in male mice can produce anxiety and aberrant socialization. Animals susceptible to CSD show activation of microglia, which have elevated levels of oxidative stress markers. We...
10.
Lehmann M, Weigel T, Cooper H, Elkahloun A, Kigar S, Herkenham M
Sci Rep . 2018 Jul; 8(1):11240. PMID: 30050134
An animal's ability to cope with or succumb to deleterious effects of chronic psychological stress may be rooted in the brain's immune responses manifested in microglial activity. Mice subjected to...