Michael K Dowd
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Explore the profile of Michael K Dowd including associated specialties, affiliations and a list of published articles.
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29
Citations
245
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Recent Articles
11.
Huang Y, Wang L, Dowd M, Wan P, Lin Y
Anticancer Res
. 2009 Jun;
29(6):2179-88.
PMID: 19528479
Background: Acquisition of metastatic ability by prostatic cancer cells is the most lethal aspect of prostatic cancer progression. (-)-Gossypol, a polyphenolic compound present in cottonseeds, possesses anti-proliferative and proapoptotic effects...
12.
Stipanovic R, Lopez Jr J, Dowd M, Puckhaber L, Duke S
Environ Entomol
. 2008 Nov;
37(5):1081-5.
PMID: 19036185
Gossypol is a constituent of the lysigenous foliar glands of cotton plants and is also found in glands in cottonseed. Gossypol exists as enantiomers because of restricted rotation around the...
13.
Dowd M, Pelitire S
J Chromatogr B Analyt Technol Biomed Life Sci
. 2008 Apr;
867(1):69-77.
PMID: 18407810
A concentrated mixture of gossypol, 6-methoxy-gossypol, and 6,6'-dimethoxy-gossypol was extracted from the root bark of St. Vincent Sea Island cotton with acetone. This extract was derivatized with R-(-)-2-amino-1-propanol to form...
14.
Mellon J, Cotty P, Dowd M
Appl Microbiol Biotechnol
. 2007 Oct;
77(3):497-504.
PMID: 17938911
Aspergillus flavus is a fungus that principally obtains resources for growth in a saprophytic mode. Yet, it also possesses the characteristics of an opportunistic pathogen with a wide, non-specific host...
15.
Ye W, Chang H, Wang L, Huang Y, Shu S, Dowd M, et al.
Anticancer Res
. 2007 Mar;
27(1A):107-16.
PMID: 17352222
Background: Multidrug resistance (MDR) is a major impediment to successful cancer chemotherapy. P-glycoprotein (P-gp), the product of the multidrug resistance 1 (MDR1) gene, acts as an efflux pump and prevents...
16.
Carruthers N, Dowd M, Stemmer P
Eur J Pharmacol
. 2006 Dec;
555(2-3):106-14.
PMID: 17141216
Calcineurin, the Ca2+/calmodulin-dependant serine/threonine phosphatase is the target for the immunosuppressant drugs FK506 and cyclosporine-A. These established calcineurin inhibitors each require an immunophilin protein cofactor. Gossypol, a polyphenol produced by...
17.
Huang Y, Wang L, Chang H, Ye W, Sugimoto Y, Dowd M, et al.
Anticancer Res
. 2006 Nov;
26(5A):3613-20.
PMID: 17094491
Background: Gossypol, a natural polyphenolic compound present in cottonseeds, possesses antiproliferative and pro-apoptotic effects in in vivo and in vitro models. There are two enantiomers, (+)-gossypol and (-)-gossypol, the latter...
18.
Huang Y, Wang L, Chang H, Ye W, Dowd M, Wan P, et al.
Anticancer Res
. 2006 Jul;
26(3A):1925-33.
PMID: 16827126
Background: Gossypol, a natural compound present in cottonseeds, displays antiproliferative and pro-apoptotic effects against various cancer cells. The (-)-gossypol enantiomer is a more potent inhibitor of cancer cell growth. Here,...
19.
Stipanovic R, Lopez Jr J, Dowd M, Puckhaber L, Duke S
J Chem Ecol
. 2006 Jun;
32(5):959-68.
PMID: 16739016
Gossypol is a sesquiterpene that occurs naturally in seed and other parts of the cotton plant. Because of restricted rotation around the binaphthyl bond, it occurs naturally as enantiomeric mixtures...
20.
Dowd M, Pelitire S
J Agric Food Chem
. 2006 Apr;
54(9):3265-70.
PMID: 16637683
6-methoxy gossypol and 6,6'-dimethoxy gossypol were isolated from the seeds and root bark of a St. Vincent Sea Island variety of cotton (AZK-267, GRIN# PI 528406). Crude mixtures of gossypol...