Michael J Trnka
Overview
Explore the profile of Michael J Trnka including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
30
Citations
1767
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
He L, Kwon D, Trnka M, Liu Y, Yang J, Li K, et al.
bioRxiv
. 2024 Oct;
PMID: 39464120
The hepatic P450 hemoproteins CYPs 4A are typical N-terminally anchored Type I endoplasmic reticulum (ER)-proteins, that are inducible by hypolipidemic drugs and other "peroxisome proliferators". They are engaged in the...
2.
Liu Y, Trnka M, He L, Burlingame A, Correia M
Mol Cell Proteomics
. 2023 Jan;
22(2):100495.
PMID: 36634736
We have previously documented that in liver cells, the multifunctional protein scaffold p62/SQSTM1 is closely associated with IκBα, an inhibitor of the transcriptional activator NF-κB. Such an intimate p62-IκBα association...
3.
Bircher J, Corcoran E, Lam T, Trnka M, Koleske A
J Biol Chem
. 2022 Aug;
298(9):102361.
PMID: 35963430
TRIO encodes a cytoskeletal regulatory protein with three catalytic domains-two guanine exchange factor (GEF) domains, GEF1 and GEF2, and a kinase domain-as well as several accessory domains that have not...
4.
Zhang M, Yang H, Ortiz G, Trnka M, Petronikolou N, Burlingame A, et al.
Chem Sci
. 2022 Jun;
13(22):6599-6609.
PMID: 35756531
Chemical probes for chromatin reader proteins are valuable tools for investigating epigenetic regulatory mechanisms and evaluating whether the target of interest holds therapeutic potential. Developing potent inhibitors for the plant...
5.
Jack A, Ferro L, Trnka M, Wehri E, Nadgir A, Nguyenla X, et al.
PLoS Biol
. 2021 Oct;
19(10):e3001425.
PMID: 34634033
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a pandemic that seriously threatens global health. SARS-CoV-2 propagates by packaging its RNA genome into membrane...
6.
Sanchez N, Kallweit L, Trnka M, Clemmer C, Al-Sady B
J Biol Chem
. 2021 Oct;
297(5):101276.
PMID: 34619147
Unique among metazoan repressive histone methyltransferases, G9a and GLP, which chiefly target histone 3 lysine 9 (H3K9), require dimerization for productive H3K9 mono (me1)- and dimethylation (me2) in vivo. Intriguingly,...
7.
Castel P, Dharmaiah S, Sale M, Messing S, Rizzuto G, Cuevas-Navarro A, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(33).
PMID: 34380736
RAS proteins are molecular switches that interact with effector proteins when bound to guanosine triphosphate, stimulating downstream signaling in response to multiple stimuli. Although several canonical downstream effectors have been...
8.
Jack A, Ferro L, Trnka M, Wehri E, Nadgir A, Nguyenla X, et al.
bioRxiv
. 2020 Sep;
PMID: 32995779
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes COVID-19, a pandemic that seriously threatens global health. SARS-CoV-2 propagates by packaging its RNA genome into membrane enclosures in host...
9.
Liu Y, Trnka M, Guan S, Kwon D, Kim D, Chen J, et al.
Mol Cell Proteomics
. 2020 Sep;
19(12):1968-1986.
PMID: 32912968
Mallory-Denk-bodies (MDBs) are hepatic protein aggregates associated with inflammation both clinically and in MDB-inducing models. Similar protein aggregation in neurodegenerative diseases also triggers inflammation and NF-κB activation. However, the precise...
10.
McGilvray P, Anghel S, Sundaram A, Zhong F, Trnka M, Fuller J, et al.
Elife
. 2020 Aug;
9.
PMID: 32820719
Membrane proteins with multiple transmembrane domains play critical roles in cell physiology, but little is known about the machinery coordinating their biogenesis at the endoplasmic reticulum. Here we describe a...