Michael J Reddish
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Explore the profile of Michael J Reddish including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
138
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Recent Articles
1.
Glass S, Reddish M, Child S, Wilkey C, Stec D, Guengerich F
J Steroid Biochem Mol Biol
. 2020 Nov;
208:105787.
PMID: 33189850
Cytochrome P450 (P450) 11B1 and 11B2 both catalyze the 11β-hydroxylation of 11-deoxycorticosterone and the subsequent 18-hydroxylation of the product. P450 11B2, but not P450 11B1, catalyzes a further C-18 oxidation...
2.
Child S, Reddish M, Glass S, Goldfarb M, Barckhausen I, Guengerich F
Arch Biochem Biophys
. 2020 Sep;
694:108596.
PMID: 32980349
Seven of the 57 human cytochrome P450 (P450) enzymes are mitochondrial and carry out important reactions with steroids and vitamins A and D. These seven P450s utilize an electron transport...
3.
Reddish M, Guengerich F
J Biol Chem
. 2019 Jul;
294(35):12975-12991.
PMID: 31296661
Human cytochrome P450 (P450) 11B2 catalyzes the formation of aldosterone, the major endogenous human mineralocorticoid. Aldosterone is important for the regulation of electrolyte homeostasis. Mutations and overexpression of P450 11B2...
4.
Guengerich F, Wilkey C, Glass S, Reddish M
J Biol Chem
. 2019 May;
294(26):10028-10041.
PMID: 31072872
Cytochrome P450 (P450, CYP) enzymes are the major catalysts involved in the oxidation of steroids as well as many other compounds. Their versatility has been explained in part by flexibility...
5.
Reddish M, Callender R, Dyer R
Biophys J
. 2017 May;
112(9):1852-1862.
PMID: 28494956
Enzymes are known to exhibit conformational flexibility. An important consequence of this flexibility is that the same enzyme reaction can occur via multiple reaction pathways on a reaction landscape. A...
6.
Davis C, Reddish M, Dyer R
Spectrochim Acta A Mol Biomol Spectrosc
. 2017 Feb;
178:185-191.
PMID: 28189834
Time-resolved temperature-jump (T-jump) coupled with fluorescence and infrared (IR) spectroscopy is a powerful technique for monitoring protein dynamics. Although IR spectroscopy of the polypeptide amide I mode is more technically...
7.
Reddish M, Vaughn M, Fu R, Dyer R
Biochemistry
. 2016 Feb;
55(10):1485-93.
PMID: 26901612
Enzymes are known to change among several conformational states during turnover. The role of such dynamic structural changes in catalysis is not fully understood. The influence of dynamics in catalysis...
8.
Kise D, Reddish M, Dyer R
J Micromech Microeng
. 2016 Feb;
25(12).
PMID: 26855478
We report on a microfluidic mixer fabrication platform that increases the versatility and flexibility of mixers for biomolecular applications. A sandwich-format design allows the application of multiple spectroscopic probes to...
9.
Reddish M, Peng H, Deng H, Panwar K, Callender R, Dyer R
J Phys Chem B
. 2014 Aug;
118(37):10854-62.
PMID: 25149276
Protein conformational heterogeneity and dynamics are known to play an important role in enzyme catalysis, but their influence has been difficult to observe directly. We have studied the effects of...
10.
Kise D, Magana D, Reddish M, Dyer R
Lab Chip
. 2013 Dec;
14(3):584-91.
PMID: 24302515
We report a continuous-flow, microfluidic mixer utilizing mid-infrared hyperspectral imaging detection, with an experimentally determined, submillisecond mixing time. The simple and robust mixer design has the microfluidic channels cut through...