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Michael J Palmer

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Articles 51
Citations 1341
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Recent Articles
1.
Nie Z, Bonnert R, Tsien J, Deng X, Higgs C, El Mazouni F, et al.
J Med Chem . 2024 Dec; 68(1):590-637. PMID: 39710971
Malaria remains a serious global health challenge, yet treatment and control programs are threatened by drug resistance. Dihydroorotate dehydrogenase (DHODH) was clinically validated as a target for treatment and prevention...
2.
Galloway J, Parsons M, Ardakani O, Falck H, Fewster R, Swindles G, et al.
Sci Total Environ . 2024 Sep; 954:176466. PMID: 39332738
Mercury (Hg) is a bioavailable and toxic element with concentrations that are persistently high or rising in some Arctic and subarctic lakes despite reduced atmospheric emissions in North America. This...
3.
Palmer M, Richardson M, Chetelat J, Spence C, Connon R, Jamieson H
Environ Pollut . 2024 Jul; 358:124480. PMID: 38968985
A holistic understanding of the chemical recovery of lakes from arsenic (As) pollution requires consideration of within-lake biogeochemical cycling of As and processes occurring in the surrounding catchment. This study...
4.
Ritonja J, Danieli C, Pana M, Palmer M, LEsperance K, Ho V, et al.
Am J Epidemiol . 2024 May; 193(9):1233. PMID: 38754871
The evidence from previous studies of serum 25-hydroxyvitamin D (25(OH)D) and ovarian cancer risk is not conclusive. However, the 25(OH)D levels were generally only measured in late adulthood, which may...
5.
Mathews J, Merchant S, Galica J, Palmer M, ODonnell J, Koven R, et al.
J Natl Cancer Inst . 2023 Dec; 116(4):506-517. PMID: 38134429
Background: Assessment of prognostic awareness (PA) in patients with advanced cancer is challenging because patient responses often indicate their hopes. The objectives of this scoping review were to summarize studies...
6.
Chetelat J, Palmer M, Paudyn K, Jamieson H, Amyot M, Harris R, et al.
J Hazard Mater . 2023 Mar; 452:131230. PMID: 36989775
Arsenic contamination from mining poses an environmental challenge due to the mobility of this redox-sensitive element. This study evaluated arsenic mobility in sediments of Yellowknife Bay (Canada), a large subarctic...
7.
Astles B, Chetelat J, Palmer M, Vermaire J
PLoS One . 2022 Dec; 17(12):e0279412. PMID: 36542618
Legacy arsenic (As) contamination from past mining operations remains an environmental concern in lakes of the Yellowknife area (Northwest Territories, Canada) due to its post-depositional mobility in sediment and potential...
8.
Sivarajah B, Simmatis B, Favot E, Palmer M, Smol J
Harmful Algae . 2021 Jul; 105:102036. PMID: 34303513
Cyanobacterial blooms have been increasing in frequency and intensity but are often considered an issue restricted to temperate and tropical lakes. Here we report on one of the first occurrences...
9.
Palmer M, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, et al.
J Med Chem . 2021 Apr; 64(9):6085-6136. PMID: 33876936
Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the development of new antimalarials. Experience with clinical candidate triazolopyrimidine DSM265 () suggested that DHODH inhibitors have great potential...
10.
Palmer M, Krupa T, Richardson H, Brundage M
Cancer Med . 2021 Apr; 10(9):3026-3034. PMID: 33835717
Background: Missing patient reported outcomes data threaten the validity of PRO-specific findings and conclusions from randomized controlled trials by introducing bias due to data missing not at random. Clinical Research...