Michael J Goldenthal
Overview
Explore the profile of Michael J Goldenthal including associated specialties, affiliations and a list of published articles.
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35
Citations
657
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Recent Articles
1.
Delhey L, Kilinc E, Yin L, Slattery J, Tippett M, Wynne R, et al.
Metab Brain Dis
. 2017 Aug;
32(6):2021-2031.
PMID: 28852932
Autism spectrum disorder (ASD) has been associated with mitochondrial dysfunction but few studies have examined the relationship between mitochondrial function and ASD symptoms. We measured Complex I and IV and...
2.
Delhey L, Kilinc E, Yin L, Slattery J, Tippett M, Rose S, et al.
J Clin Med
. 2017 Feb;
6(2).
PMID: 28208802
Treatment for mitochondrial dysfunction is typically guided by expert opinion with a paucity of empirical evidence of the effect of treatment on mitochondrial activity. We examined citrate synthase and Complex...
3.
Goldenthal M
Heart Fail Rev
. 2016 Feb;
21(2):137-55.
PMID: 26886225
As the heart is an energy-demanding organ, impaired cardiac energy metabolism and mitochondrial function have been inexorably linked to cardiac dysfunction. There is a growing recognition that mitochondrial dysfunction contributes...
4.
Frye R, Cox D, Slattery J, Tippett M, Kahler S, Granpeesheh D, et al.
Sci Rep
. 2016 Jan;
6:19544.
PMID: 26822410
Phelan-McDermid Syndrome (PMS), which is defined by a deletion within 22q13, demonstrates significant phenotypic variation. Given that six mitochondrial genes are located within 22q13, including complex I and IV genes,...
5.
Shoar Z, Goldenthal M, De Luca F, Suarez E
Endocr Res
. 2015 Oct;
41(1):49-56.
PMID: 26513277
Objectives: The objectives of our study were to compare the mitochondrial enzyme activity between obese and non-obese children and to assess the association between mitochondrial DNA content and function and...
6.
Goldenthal M, Damle S, Sheth S, Shah N, Melvin J, Jethva R, et al.
Biomark Med
. 2015 Oct;
9(10):957-65.
PMID: 26439018
Aim: Mitochondrial function studies in autism spectrum disorders (ASD) have detected skeletal muscle mitochondrial enzyme deficiencies in respiratory complex (RC) activities. As a muscle biopsy is expensive and invasive, we...
7.
Khurana D, Valencia I, Goldenthal M, Legido A
Semin Pediatr Neurol
. 2013 Dec;
20(3):176-87.
PMID: 24331359
Epilepsy is the most common neurologic disorder worldwide and is characterized by recurrent unprovoked seizures. The mitochondrial (mt) respiratory chain is the final common pathway for cellular energy production through...
8.
Legido A, Jethva R, Goldenthal M
Semin Pediatr Neurol
. 2013 Dec;
20(3):163-75.
PMID: 24331358
Using data of the current prevalence of autism as 200:10,000 and a 1:2000 incidence of definite mitochondrial (mt) disease, if there was no linkage of autism spectrum disorder (ASD) and...
9.
Goldenthal M, Kuruvilla T, Damle S, Salganicoff L, Sheth S, Shah N, et al.
Mol Genet Metab
. 2011 Dec;
105(3):457-62.
PMID: 22189081
Making a diagnosis of mitochondrial disease (MD) is extremely challenging and often employs the analysis of respiratory complex (RC) activities in biopsied skeletal muscle. Given both the invasive nature and...
10.
Yorns Jr W, Valencia I, Jayaraman A, Sheth S, Legido A, Goldenthal M
J Child Neurol
. 2011 Nov;
27(3):398-401.
PMID: 22114216
The authors describe mitochondrial studies in a 6-year-old patient with a seizure disorder that can be seen in myoclonic epilepsy and ragged red fibers. Using a recently developed noninvasive approach,...