Michael J Conboy
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Explore the profile of Michael J Conboy including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
3870
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Recent Articles
1.
Skinner C, Conboy M, Conboy I
Geroscience
. 2025 Jan;
PMID: 39825170
Biological age estimation from DNA methylation and determination of relevant biomarkers is an active research problem which has predominantly been tackled with black-box penalized regression. Machine learning is used to...
2.
Sviercovich A, Mei X, Xie G, Conboy M, Conboy I
Ageing Res Rev
. 2024 Dec;
104:102641.
PMID: 39672207
This concise review provides new perspectives on systemic reduction of tissue aging by comparing different strategies, such as heterochronic parabiosis, injections of young blood plasma, neutral blood exchange (NBE) and...
3.
Skinner C, Conboy M, Conboy I
bioRxiv
. 2024 Oct;
PMID: 39416129
Key Findings: There is no apparent biological significance of the CpGs selected by first- and next-generation clocksThe range of residuals for first- and next-generation clock predications on healthy samples is...
4.
Kim D, Kiprov D, Luellen C, Lieb M, Liu C, Watanabe E, et al.
Geroscience
. 2023 Nov;
46(2):2795.
PMID: 37930507
No abstract available.
5.
Mei X, Blanchard J, Luellen C, Conboy M, Conboy I
Aging (Albany NY)
. 2023 Sep;
15(17):8552-8575.
PMID: 37702598
This study shows that Elastic Net (EN) DNA methylation (DNAme) clocks have low accuracy of predictions for individuals of the same age and a low resolution between healthy and disease...
6.
Kim D, Kiprov D, Luellen C, Lieb M, Liu C, Watanabe E, et al.
Geroscience
. 2022 Aug;
44(6):2701-2720.
PMID: 35999337
This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct measurement of biological age. Our results support the hypothesis that, similar to mice,...
7.
Mehdipour M, Amiri P, Liu C, DeCastro J, Kato C, Skinner C, et al.
Nat Protoc
. 2022 Aug;
17(11):2469-2493.
PMID: 35986217
We describe a small-animal blood exchange approach developed for aging research as an alternative to heterochronic parabiosis or plasma injections. In parabiosis, animals are surgically coupled, which has several disadvantages,...
8.
Jeon O, Mehdipour M, Gil T, Kang M, Aguirre N, Robinson Z, et al.
Nat Metab
. 2022 Jul;
4(8):995-1006.
PMID: 35902645
Ageing is the largest risk factor for many chronic diseases. Studies of heterochronic parabiosis, substantiated by blood exchange and old plasma dilution, show that old-age-related factors are systemically propagated and...
9.
Kiprov D, Herskowitz A, Kim D, Lieb M, Liu C, Watanabe E, et al.
F1000Res
. 2022 May;
10:1189.
PMID: 35464182
Many patients with COVID-19 experience a range of debilitating symptoms months after being infected, a syndrome termed long-haul COVID. A 68-year-old male presented with lung opacity, fatigue, physical and cognitive...
10.
Liu C, Wong N, Watanabe E, Hou W, Biral L, DeCastro J, et al.
Rejuvenation Res
. 2022 Mar;
25(2):95-109.
PMID: 35323026
Metabolic proteomics has been widely used to characterize dynamic protein networks in many areas of biomedicine, including in the arena of tissue aging and rejuvenation. Bioorthogonal noncanonical amino acid tagging...