Michael J Ciesielski
Overview
Explore the profile of Michael J Ciesielski including associated specialties, affiliations and a list of published articles.
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32
Citations
784
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Recent Articles
1.
Galbo Jr P, Madsen A, Liu Y, Peng M, Wei Y, Ciesielski M, et al.
Clin Cancer Res
. 2023 Dec;
30(4):865-876.
PMID: 38060213
Purpose: The abundance and biological contribution of cancer-associated fibroblasts (CAF) in glioblastoma (GBM) are poorly understood. Here, we aim to uncover its molecular signature, cellular roles, and potential tumorigenesis implications....
2.
Ahluwalia M, Reardon D, Abad A, Curry W, Wong E, Figel S, et al.
J Clin Oncol
. 2022 Dec;
41(7):1453-1465.
PMID: 36521103
Purpose: Despite intensive treatment with surgery, radiation therapy, temozolomide (TMZ) chemotherapy, and tumor-treating fields, mortality of newly diagnosed glioblastoma (nGBM) remains very high. SurVaxM is a peptide vaccine conjugate that...
3.
Shu S, Yang Y, Allen C, Maguire O, Minderman H, Sen A, et al.
Sci Rep
. 2019 Mar;
9(1):4959.
PMID: 30874569
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
4.
Davis P, Davis F, Lin H, Bergh J, Mousa S, Hercbergs A, et al.
Expert Rev Endocrinol Metab
. 2019 Feb;
1(6):753-761.
PMID: 30754150
Integrin αVβ3 is a structural protein of the plasma membrane that transduces signals from extracellular matrix proteins and has recently been shown to contain a novel receptor for thyroid hormone....
5.
Ciesielski M, Bu Y, Munich S, Teegarden P, Smolinski M, Clements J, et al.
J Neurooncol
. 2018 Sep;
140(3):519-527.
PMID: 30238350
Purpose: A major challenge to developing new therapies for patients with malignant brain tumors is that relatively few small molecule anticancer drugs penetrate the blood-brain barrier (BBB) well enough to...
6.
Shu S, Yang Y, Allen C, Maguire O, Minderman H, Sen A, et al.
Sci Rep
. 2018 Aug;
8(1):12905.
PMID: 30150674
Local acidification of stroma is proposed to favour pre-metastatic niche formation but the mechanism of initiation is unclear. We investigated whether Human Melanoma-derived exosomes (HMEX) could reprogram human adult dermal...
7.
Fenstermaker R, Figel S, Qiu J, Barone T, Dharma S, Winograd E, et al.
Clin Cancer Res
. 2018 Mar;
24(11):2642-2652.
PMID: 29540489
Survivin is an inhibitor of apoptosis protein (IAP) that is highly expressed in many cancers and represents an attractive molecule for targeted cancer therapy. Although primarily regarded as an intracellular...
8.
Galbo Jr P, Ciesielski M, Figel S, Maguire O, Qiu J, Wiltsie L, et al.
Oncotarget
. 2018 Feb;
8(70):114722-114735.
PMID: 29383115
Glioma cells release exosomes in culture and into the extracellular matrix . These nanobodies transport an array of biomolecules and are capable of mediating cell-cell communication. Circulating exosomes in cancer...
9.
Winograd E, Ciesielski M, Fenstermaker R
Immunotherapy
. 2016 Dec;
8(11):1293-1308.
PMID: 27993092
Glioblastoma is the most common primary brain cancer. Aggressive treatment with surgery, radiation therapy and chemotherapy provides limited overall survival benefit. Glioblastomas have a formidable tumor microenvironment that is hostile...
10.
Fenstermaker R, Ciesielski M, Qiu J, Yang N, Frank C, Lee K, et al.
Cancer Immunol Immunother
. 2016 Sep;
65(11):1339-1352.
PMID: 27576783
Survivin is an anti-apoptotic protein that is highly expressed in many cancers, including malignant gliomas. Preclinical studies established that the conjugated survivin peptide mimic SurVaxM (SVN53-67/M57-KLH) could stimulate an anti-tumor...