Michael F Callahan
Overview
Explore the profile of Michael F Callahan including associated specialties, affiliations and a list of published articles.
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25
Citations
572
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0
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Recent Articles
1.
Axiak-Bechtel S, Leach S, Newton-Northup J, Milner R, Fox-Alvarez S, Fagman L, et al.
J Vet Intern Med
. 2023 Oct;
37(6):2344-2355.
PMID: 37897303
Background: The melanocortin 4 antagonist TCMCB07 is safe and effective in reversing cachexia caused by sepsis or cancer in rodents. The safety and pharmacokinetics of TCMCB07 are demonstrated in healthy...
2.
Axiak-Bechtel S, Leach S, Scholten D, Newton-Northup J, Johnson B, Durham H, et al.
Pharmacol Res Perspect
. 2021 May;
9(3):e00777.
PMID: 34014033
The melanocortin-4 receptor (MC4R) antagonistic peptide TCMCB07 was developed for the treatment of cachexia. The objectives of this study were to examine pharmacokinetics and safety of TCMCB07 administered subcutaneously to...
3.
Liu Y, Shao Q, Cheng H, Li T, Zhang X, Callahan M, et al.
J Pharmacol Exp Ther
. 2021 Mar;
377(3):316-325.
PMID: 33722881
Ca/calmodulin-dependent protein kinase II (CaMKII) is upregulated in congestive heart failure (CHF), contributing to electrical, structural, and functional remodeling. CaMKII inhibition is known to improve CHF, but its direct cardiac...
4.
Stone A, Loeser R, Callahan M, McNulty M, Long D, Yammani R, et al.
Cartilage
. 2020 Sep;
13(2_suppl):1442S-1455S.
PMID: 32940061
Objective: Meniscus injury and the hypoxia-inducible factor (HIF) pathway are independently linked to osteoarthritis pathogenesis, but the role of the meniscus HIF pathway remains unclear. We sought to identify and...
5.
Zhu X, Callahan M, Gruber K, Szumowski M, Marks D
J Clin Invest
. 2020 Jun;
130(9):4921-4934.
PMID: 32544087
Cachexia, a devastating wasting syndrome characterized by severe weight loss with specific losses of muscle and adipose tissue, is driven by reduced food intake, increased energy expenditure, excess catabolism, and...
6.
Willey J, Bracey D, Gallagher P, Tallant E, Wiggins W, Callahan M, et al.
J Bone Joint Surg Am
. 2016 Jan;
98(1):48-55.
PMID: 26738903
Background: Radiation-induced fibrosis (RIF) of musculoskeletal tissue is a common complication of radiation therapy for extremity soft-tissue sarcoma, with no standardized strategy for prevention and treatment. Angiotensin-(1-7) (Ang-[1-7]), a well-tolerated...
7.
Shao Q, Cheng H, Callahan M, Kitzman D, Li W, Cheng C
Int J Cardiol
. 2015 Dec;
204:229-41.
PMID: 26681542
Background: Altered nitric oxide synthase (NOS) has been implicated in the pathophysiology of heart failure (HF). Recent evidence links hypothyroidism to the pathology of HF. However, the precise mechanisms are...
8.
McNulty M, Loeser R, Davey C, Callahan M, Ferguson C, Carlson C
Cartilage
. 2015 Jun;
2(4):354-63.
PMID: 26069594
Objective: Accurate histological assessment of osteoarthritis (OA) is critical in studies evaluating the effects of interventions on disease severity. The purpose of the present study was to develop a histological...
9.
Kowalczewski C, Tombyln S, Wasnick D, Hughes M, Ellenburg M, Callahan M, et al.
Biomaterials
. 2014 Jan;
35(10):3220-8.
PMID: 24439399
Absorbable collagen sponges (ACS) are used clinically as carriers of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote bone regeneration. ACS exhibit ectopic bone growth due to delivery of...
10.
Nunez F, Callahan M, Trach S, Burnett L, Kislukhin V, Smith T, et al.
Artif Cells Nanomed Biotechnol
. 2013 Jan;
41(5):293-303.
PMID: 23305143
Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein...