Michael E ODonnell
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Explore the profile of Michael E ODonnell including associated specialties, affiliations and a list of published articles.
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Articles
51
Citations
1316
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Recent Articles
1.
He Q, Wang F, Yao N, ODonnell M, Li H
Nat Commun
. 2024 Nov;
15(1):9676.
PMID: 39516490
No abstract available.
2.
Mayle R, Holloman W, ODonnell M
J Biol Chem
. 2024 Oct;
300(12):107918.
PMID: 39454951
Cell biology and genetic studies have demonstrated that DNA double-strand break (DSB) repair can be performed using an RNA transcript that spans the site of the DNA break as a...
3.
Mayle R, Holloman W, ODonnell M
bioRxiv
. 2024 Oct;
PMID: 39386629
Cell biology and genetic studies have demonstrated that DNA double strand break (DSB) repair can be performed using an RNA transcript that spans the site of the DNA break as...
4.
He Q, Wang F, Yao N, ODonnell M, Li H
Nat Commun
. 2024 Sep;
15(1):7847.
PMID: 39245668
In eukaryotes, the leading strand DNA is synthesized by Polε and the lagging strand by Polδ. These replicative polymerases have higher processivity when paired with the DNA clamp PCNA. While...
5.
Yuan Z, Georgescu R, Yao N, Yurieva O, ODonnell M, Li H
Science
. 2024 Aug;
385(6708):eadk5901.
PMID: 39088616
The proliferating cell nuclear antigen (PCNA) clamp encircles DNA to hold DNA polymerases (Pols) to DNA for processivity. The Ctf18-RFC PCNA loader, a replication factor C (RFC) variant, is specific...
6.
Wang F, He Q, Yao N, ODonnell M, Li H
Nat Struct Mol Biol
. 2024 Jun;
31(11):1680-1691.
PMID: 38871854
Humans have three different proliferating cell nuclear antigen (PCNA) clamp-loading complexes: RFC and CTF18-RFC load PCNA onto DNA, but ATAD5-RFC can only unload PCNA from DNA. The underlying structural basis...
7.
He Q, Wang F, ODonnell M, Li H
Proc Natl Acad Sci U S A
. 2024 Apr;
121(18):e2319727121.
PMID: 38669181
The DNA sliding clamp PCNA is a multipurpose platform for DNA polymerases and many other proteins involved in DNA metabolism. The topologically closed PCNA ring needs to be cracked open...
8.
Zheng F, Yao N, Georgescu R, Li H, ODonnell M
Sci Adv
. 2024 Mar;
10(9):eadl1739.
PMID: 38427736
During DNA replication, the proliferating cell nuclear antigen (PCNA) clamps are loaded onto primed sites for each Okazaki fragment synthesis by the AAA heteropentamer replication factor C (RFC). PCNA encircling...
9.
Langston L, Georgescu R, ODonnell M
Proc Natl Acad Sci U S A
. 2023 Dec;
120(52):e2316466120.
PMID: 38109526
DNA replication in all cells begins with the melting of base pairs at the duplex origin to allow access to single-stranded DNA templates which are replicated by DNA polymerases. In...
10.
Zheng F, Georgescu R, Yao N, ODonnell M, Li H
Cell Rep
. 2023 Jul;
42(7):112694.
PMID: 37392384
Rad24-RFC (replication factor C) loads the 9-1-1 checkpoint clamp onto the recessed 5' ends by binding a 5' DNA at an external surface site and threading the 3' single-stranded DNA...