Michael E Birnbaum
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Explore the profile of Michael E Birnbaum including associated specialties, affiliations and a list of published articles.
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57
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2219
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Recent Articles
1.
Gordon K, Perez C, Garmilla A, Lam M, Aw J, Datta A, et al.
J Immunother Cancer
. 2025 Feb;
13(2).
PMID: 39933837
Background: Chimeric antigen receptor (CAR) therapies have demonstrated potent efficacy in treating B-cell malignancies, but have yet to meaningfully translate to solid tumors. Nonetheless, they are of particular interest for...
2.
Chan C, Loh J, Sin W, Teo D, Tan N, Nagarajan C, et al.
Mol Ther Nucleic Acids
. 2025 Feb;
36(1):102444.
PMID: 39897577
Nucleic acid amplification tests (NAATs) have enabled fast and sensitive detection of virus infections but are unable to discriminate between live and dead/inert viral fragments or between latent and reactivated...
3.
Lagattuta K, Kohlgruber A, Abdelfattah N, Nathan A, Rumker L, Birnbaum M, et al.
Cell Rep
. 2024 Dec;
44(1):115098.
PMID: 39731734
The amino acid sequence of the T cell receptor (TCR) varies between T cells of an individual's immune system. Particular TCR residues nearly guarantee mucosal-associated invariant T (MAIT) and natural...
4.
5.
Xu E, Smith B, Conce Alberto W, Walsh M, Lim B, Hoffman M, et al.
bioRxiv
. 2024 Sep;
PMID: 39345591
Tumor-infiltrating-lymphocyte (TIL) therapy has demonstrated that endogenous T cells can be harnessed to initiate an effective anti-tumor response. Despite clinical promise, current TIL production protocols involve weeks-long expansions which can...
6.
Lu R, Ang Y, Cheung K, Quek K, Sin W, Lee E, et al.
Adv Sci (Weinh)
. 2024 Aug;
11(40):e2309920.
PMID: 39175207
Cytokines, crucial in immune modulation, impact disease progression when their secretion is dysregulated. Existing methods for profiling cytokine secretion suffer from time-consuming and labor-intensive processes and often fail to capture...
7.
Gaglione S, Rosales T, Schmidt-Hong L, Baker B, Birnbaum M
Proc Natl Acad Sci U S A
. 2024 Jul;
121(31):e2406615121.
PMID: 39042676
SARS-CoV-2infection can induce multisystem inflammatory syndrome in children, which resembles superantigen-induced toxic shock syndrome. Recent work has suggested that the SARS-CoV-2 spike (S) protein could act as a superantigen by...
8.
Jeon H, Perez C, Kyung T, Birnbaum M, Han J
Anal Chem
. 2024 Jun;
96(26):10780-10790.
PMID: 38889002
This study introduces a T cell enrichment process, capitalizing on the size differences between activated and unactivated T cells to facilitate the isolation of activated, transducible T cells. By employing...
9.
Sin W, Jagannathan N, Teo D, Kairi F, Fong S, Tan J, et al.
Nat Biomed Eng
. 2024 Jun;
8(12):1571-1591.
PMID: 38834752
The manufacturing of autologous chimaeric antigen receptor (CAR) T cells largely relies either on fed-batch and manual processes that often lack environmental monitoring and control or on bioreactors that cannot...
10.
Gordon K, Perez C, Garmilla A, Lam M, Aw J, Datta A, et al.
bioRxiv
. 2024 May;
PMID: 38766252
Chimeric antigen receptor therapies have demonstrated potent efficacy in treating B cell malignancies, but have yet to meaningfully translate to solid tumors. Here, we utilize our pooled screening platform, CARPOOL,...