Michael E Bekier 2nd
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Explore the profile of Michael E Bekier 2nd including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
284
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Recent Articles
1.
Bekier 2nd M, Bekier M, Pinarbasi E, Mesojedec J, Ghaffari L, de Majo M, et al.
bioRxiv
. 2025 Feb;
PMID: 39975323
Cytoplasmic TDP43 mislocalization and aggregation are pathological hallmarks of amyotrophic lateral sclerosis (ALS). However, the initial cellular insults that lead to TDP43 mislocalization remain unclear. In this study, we demonstrate...
2.
Ranjan Sahoo B, Bekier 2nd M, Liu Z, Kocman V, Stoddard A, Anantharamaiah G, et al.
J Mol Biol
. 2019 Dec;
432(4):1020-1034.
PMID: 31866295
Apolipoproteins are involved in pathological conditions of Alzheimer's disease (AD), and it has been reported that truncated apolipoprotein fragments and β-amyloid (Aβ) peptides coexist as neurotoxic heteromers within the plaques....
3.
Zhang X, Wang L, Ireland S, Ahat E, Li J, Bekier 2nd M, et al.
Autophagy
. 2019 Mar;
15(10):1787-1800.
PMID: 30894053
It has been indicated that the Golgi apparatus contributes to autophagy, but how it is involved in autophagosome formation and maturation is not well understood. Here we show that amino...
4.
Ahat E, Xiang Y, Zhang X, Bekier 2nd M, Wang Y
Mol Biol Cell
. 2019 Jan;
30(6):766-777.
PMID: 30649990
The Golgi apparatus is a membrane-bound organelle that serves as the center for trafficking and processing of proteins and lipids. To perform these functions, the Golgi forms a multilayer stacked...
5.
Bekier 2nd M, Wang L, Li J, Huang H, Tang D, Zhang X, et al.
Mol Biol Cell
. 2017 Aug;
28(21):2833-2842.
PMID: 28814501
Golgi reassembly stacking protein of 65 kDa (GRASP65) and Golgi reassembly stacking protein of 55 kDa (GRASP55) were originally identified as Golgi stacking proteins; however, subsequent GRASP knockdown experiments yielded...
6.
Ji W, Arnst C, Tipton A, Bekier 2nd M, Taylor W, Yen T, et al.
PLoS One
. 2016 Apr;
11(4):e0153518.
PMID: 27082996
OTSSP167 was recently characterized as a potent inhibitor for maternal embryonic leucine zipper kinase (MELK) and is currently tested in Phase I clinical trials for solid tumors that have not...
7.
Joshi G, Bekier 2nd M, Wang Y
Front Neurosci
. 2015 Oct;
9:340.
PMID: 26441511
The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique...
8.
Tipton A, Ji W, Sturt-Gillespie B, Bekier 2nd M, Wang K, Taylor W, et al.
J Biol Chem
. 2013 Oct;
288(49):35149-58.
PMID: 24151075
MPS1 kinase is an essential component of the spindle assembly checkpoint (SAC), but its functioning mechanisms are not fully understood. We have shown recently that direct interaction between BUBR1 and...
9.
Date D, Dreier M, Borton M, Bekier 2nd M, Taylor W
J Biochem
. 2012 Mar;
151(4):361-9.
PMID: 22383538
The chromosomal passenger complex (CPC) senses tension defects at the kinetochore to activate the spindle assembly checkpoint, and helps to position the cleavage furrow. The CPC, consisting of INCENP, Survivin,...
10.
Dreier M, Bekier 2nd M, Taylor W
J Cell Sci
. 2011 Sep;
124(Pt 17):2976-87.
PMID: 21878504
Tumor cells are commonly aneuploid, a condition contributing to cancer progression and drug resistance. Understanding how chromatids are linked and separated at the appropriate time will help uncover the basis...