Michael Dragunow
Overview
Explore the profile of Michael Dragunow including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
956
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Recent Articles
1.
Sharma R, Oyagawa C, Abbasi H, Dragunow M, Conole D
Trends Pharmacol Sci
. 2024 Oct;
45(11):997-1017.
PMID: 39438155
Central nervous system (CNS) drug development is plagued by high clinical failure rate. Phenotypic assays promote clinical translation of drugs by reducing complex brain diseases to measurable, clinically valid phenotypes....
2.
Morgan C, Thomas D, Shao X, Mahroo A, Manson T, Suresh V, et al.
NMR Biomed
. 2024 Sep;
37(12):e5256.
PMID: 39252500
Water exchange rate (Kw) across the blood-brain barrier (BBB) is an important physiological parameter that may provide new insight into ageing and neurodegenerative disease. Recently, two non-invasive arterial spin labelling...
3.
Thumbadoo K, Dieriks B, Murray H, Swanson M, Yoo J, Mehrabi N, et al.
Brain
. 2024 May;
147(10):3547-3561.
PMID: 38703371
Pathogenic variants in the UBQLN2 gene cause X-linked dominant amyotrophic lateral sclerosis and/or frontotemporal dementia characterized by ubiquilin 2 aggregates in neurons of the motor cortex, hippocampus and spinal cord....
4.
Ermini F, Low V, Song J, Tan A, Faull R, Dragunow M, et al.
NPJ Parkinsons Dis
. 2024 Apr;
10(1):90.
PMID: 38664405
Gingipains are protease virulence factors produced by Porphyromonas gingivalis, a Gram-negative bacterium best known for its role in chronic periodontitis. Gingipains were recently identified in the middle temporal gyrus of...
5.
Wiseman J, Murray H, Faull R, Dragunow M, Turner C, Dieriks B, et al.
NPJ Parkinsons Dis
. 2024 Jan;
10(1):1.
PMID: 38167744
In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates form a myriad of conformational and truncational variants. Most antibodies used to detect and quantify α-Syn in the human brain...
6.
Stevenson T, Johnson R, Savistchenko J, Rustenhoven J, Woolf Z, Smyth L, et al.
Sci Rep
. 2022 Oct;
12(1):17314.
PMID: 36243723
Parkinson's disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn). Pericytes and microglia, two non-neuronal cells contain α-syn in the...
7.
Turner C, McLay J, Hermans I, Correia J, Bok A, Mehrabi N, et al.
Pathology
. 2022 Jan;
54(4):417-424.
PMID: 35082053
Tumour infiltrating lymphocyte (TIL) density is prognostically significant in various tumours, but few studies have investigated its significance in meningioma. This study aimed to investigate how TIL density differs by...
8.
Woolf Z, Swanson M, Smyth L, Mee E, Schweder P, Heppner P, et al.
Neurooncol Adv
. 2021 Jul;
3(1):vdab031.
PMID: 34286275
Background: Microglia and tumor-associated macrophages (TAMs) constitute up to half of the total tumor mass of glioblastomas. Despite these myeloid populations being ontogenetically distinct, they have been largely conflated. Recent...
9.
Woolf Z, Stevenson T, Lee K, Jung Y, Park T, Curtis M, et al.
STAR Protoc
. 2021 May;
2(2):100518.
PMID: 34027479
Microglia are the primary innate immune effectors of the central nervous system. Although numerous protocols have been developed to isolate fetal mouse microglia, the isolation of adult mouse microglia has...
10.
Highet B, Anekal P, Ryan B, Murray H, Coppieters N, Dieriks B, et al.
J Neurochem
. 2020 Dec;
157(4):1270-1283.
PMID: 33368239
In situ hybridization (ISH) is a powerful tool that can be used to localize mRNA expression in tissue samples. Combining ISH with immunohistochemistry (IHC) to determine cell type provides cellular...