Environmental Robustness of the Global Yeast Genetic Interaction Network

Overview

Journal Science

Specialty Science

Date 2021 May 7

PMID 33958448

Citations 30

Authors

Michael Costanzo

Jing Hou

Vincent Messier

Justin Nelson

Mahfuzur Rahman

Benjamin VanderSluis

Wen Wang

Carles Pons

Catherine Ross

Matej Usaj

Bryan-Joseph San Luis

Emira Shuteriqi

Elizabeth N Koch

Patrick Aloy

Chad L Myers

Charles Boone

Brenda Andrews

Affiliations

Soon will be listed here.

Abstract

Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a global scale, but the environmental influence on the plasticity of genetic networks has not been examined systematically. To assess environmental rewiring of genetic networks, we examined 14 diverse conditions and scored 30,000 functionally representative yeast gene pairs for dynamic, differential interactions. Different conditions revealed novel differential interactions, which often uncovered functional connections between distantly related gene pairs. However, the majority of observed genetic interactions remained unchanged in different conditions, suggesting that the global yeast genetic interaction network is robust to environmental perturbation and captures the fundamental functional architecture of a eukaryotic cell.

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