Michael C Sabel
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Explore the profile of Michael C Sabel including associated specialties, affiliations and a list of published articles.
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22
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1431
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Recent Articles
11.
Reifenberger G, Weber R, Riehmer V, Kaulich K, Willscher E, Wirth H, et al.
Int J Cancer
. 2014 Mar;
135(8):1822-31.
PMID: 24615357
The prognosis of glioblastoma, the most malignant type of glioma, is still poor, with only a minority of patients showing long-term survival of more than three years after diagnosis. To...
12.
Delic S, Lottmann N, Stelzl A, Liesenberg F, Wolter M, Gotze S, et al.
Neuro Oncol
. 2013 Dec;
16(2):179-90.
PMID: 24305703
Background Diffusely infiltrative growth of human astrocytic gliomas is one of the major obstacles to successful tumor therapy. Thorough insights into the molecules and pathways signaling glioma cell invasion thus...
13.
Wick W, Meisner C, Hentschel B, Platten M, Schilling A, Wiestler B, et al.
Neurology
. 2013 Sep;
81(17):1515-22.
PMID: 24068788
Objective: To explore whether the isocitrate dehydrogenase 1 (IDH1) or 1p/19q status determines the prognostic vs predictive role of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation in the Neuro-Oncology Working Group of...
14.
Vogel S, Peters C, Etminan N, Borger V, Schimanski A, Sabel M, et al.
Biochem Biophys Res Commun
. 2013 Jan;
431(3):428-32.
PMID: 23333382
Hepatocyte-growth factor (HGF) is expressed by glioblastomas and contributes to their growth, migration and invasion. HGF also mediates migration of mesenchymal stem cells (MSC) to sites of apoptotic cell death....
15.
Felsberg J, Thon N, Eigenbrod S, Hentschel B, Sabel M, Westphal M, et al.
Int J Cancer
. 2011 Mar;
129(3):659-70.
PMID: 21425258
Epigenetic silencing of the O(6) -methylguanine-DNA methyltransferase (MGMT) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastoma recurrence is associated with...
16.
Toedt G, Barbus S, Wolter M, Felsberg J, Tews B, Blond F, et al.
Int J Cancer
. 2010 May;
128(5):1095-103.
PMID: 20473936
To identify novel glioma-associated pathomechanisms and molecular markers, we performed an array-based comparative genomic hybridization analysis of 131 diffuse astrocytic gliomas, including 87 primary glioblastomas (pGBIV), 13 secondary glioblastomas (sGBIV),...
17.
Felsberg J, Wolter M, Seul H, Friedensdorf B, Goppert M, Sabel M, et al.
Acta Neuropathol
. 2010 Feb;
119(4):501-7.
PMID: 20131059
Diffusely infiltrating cerebral gliomas frequently carry point mutations in codon 132 of the isocitrate dehydrogenase 1 (IDH1) gene or in codon 172 of the IDH2 gene, which are both clinically...
18.
Wick W, Hartmann C, Engel C, Stoffels M, Felsberg J, Stockhammer F, et al.
J Clin Oncol
. 2009 Nov;
27(35):5874-80.
PMID: 19901110
Purpose: The standard of care for anaplastic gliomas is surgery followed by radiotherapy. The NOA-04 phase III trial compared efficacy and safety of radiotherapy followed by chemotherapy at progression with...
19.
Felsberg J, Rapp M, Loeser S, Fimmers R, Stummer W, Goeppert M, et al.
Clin Cancer Res
. 2009 Oct;
15(21):6683-93.
PMID: 19861461
Purpose: Despite multimodal aggressive treatment glioblastoma patients still face a rather poor prognosis. Recent data indicate that certain molecular markers, in particular MGMT promoter hypermethylation, are associated with response to...
20.
Trost D, Ehrler M, Fimmers R, Felsberg J, Sabel M, Kirsch L, et al.
Int J Cancer
. 2007 Feb;
120(11):2368-76.
PMID: 17285580
Deletions on chromosomes 1p and 19q are associated with favorable prognosis in patients with oligodendroglial tumors. The aim of our study was to identify additional genomic aberrations linked to patient...