Michael Brand
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Explore the profile of Michael Brand including associated specialties, affiliations and a list of published articles.
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194
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Recent Articles
21.
Suzzi S, Ahrendt R, Hans S, Semenova S, Chekuru A, Wirsching P, et al.
PLoS Genet
. 2021 Sep;
17(9):e1009794.
PMID: 34516550
LRRK2 gain-of-function is considered a major cause of Parkinson's disease (PD) in humans. However, pathogenicity of LRRK2 loss-of-function in animal models is controversial. Here we show that deletion of the...
22.
Kesavan G, Machate A, Brand M
Zebrafish
. 2021 Sep;
18(6):369-373.
PMID: 34495758
Genetically encoded fluorescent tags such as green fluorescent protein fused to protein have revolutionized cell biology as they permit high-resolution protein imaging in live systems. Split fluorescent proteins, with a...
23.
Desch S, Freund A, Akin I, Behnes M, Preusch M, Zelniker T, et al.
N Engl J Med
. 2021 Aug;
385(27):2544-2553.
PMID: 34459570
Background: Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest. However, the benefits of early coronary angiography and revascularization in resuscitated patients without electrocardiographic evidence of ST-segment elevation are...
24.
Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck J, et al.
J Med Chem
. 2021 Jul;
64(14):10102-10123.
PMID: 34255515
CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development. They each comprise 10 domains through which they interact with >400 proteins, making...
25.
Brand M, Wang L, Agnello S, Gazzola S, Gall F, Raguz L, et al.
Angew Chem Int Ed Engl
. 2021 Mar;
60(28):15613-15621.
PMID: 33730410
Leucinostatin A is one of the most potent antiprotozoal compounds ever described, but little was known on structure-activity relationships (SAR). We used Trypanosoma brucei as a protozoal model organism to...
26.
Falkhausen R, Mitsimponas K, Adler W, Brand M, von Wilmowsky C
J Craniomaxillofac Surg
. 2021 Mar;
49(6):468-479.
PMID: 33715966
The aim of this study was to determine whether patients benefit from a secondary reconstruction since it carries the risks of no improvement or worsening of their current situation. Patients...
27.
Keil S, Gupta M, Brand M, Knopf F
Dev Dyn
. 2021 Feb;
250(9):1368-1380.
PMID: 33638212
Background: Heparan sulfate proteoglycan (HSPG) expression is found in many animal tissues and regulates growth factor signaling such as of Fibroblast growth factors (Fgf), Wingless/Int (Wnt) and Hedgehog (HH). Glypicans,...
28.
Hans S, Zoller D, Hammer J, Stucke J, Spiess S, Kesavan G, et al.
Nat Commun
. 2021 Feb;
12(1):1125.
PMID: 33602923
Conditional gene inactivation is a powerful tool to determine gene function when constitutive mutations result in detrimental effects. The most commonly used technique to achieve conditional gene inactivation employs the...
29.
Pawelke J, Brand M, Hans S, Hideghety K, Karsch L, Lessmann E, et al.
Radiother Oncol
. 2021 Feb;
158:7-12.
PMID: 33587970
Background And Purpose: In consequence of a previous study, where no protecting proton Flash effect was found for zebrafish embryos, potential reasons and requirements for inducing a Flash effect should...
30.
Tsata V, Mollmert S, Schweitzer C, Kolb J, Mockel C, Bohm B, et al.
Dev Cell
. 2021 Jan;
56(4):509-524.e9.
PMID: 33412105
In mammals, perivascular cell-derived scarring after spinal cord injury impedes axonal regrowth. In contrast, the extracellular matrix (ECM) in the spinal lesion site of zebrafish is permissive and required for...