Gokul Kesavan
Overview
Explore the profile of Gokul Kesavan including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
344
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Recent Articles
1.
Mattonet K, Riemslagh F, Guenther S, Prummel K, Kesavan G, Hans S, et al.
Sci Adv
. 2022 Aug;
8(35):eabn2082.
PMID: 36044573
Endothelial specification is a key event during embryogenesis; however, when, and how, endothelial cells separate from other lineages is poorly understood. In zebrafish, Npas4l is indispensable for endothelial specification by...
2.
Kesavan G
Mol Biotechnol
. 2021 Sep;
65(2):138-145.
PMID: 34586618
Gene and cell therapies have shown tremendous advancement in the last 5 years. Prominent examples include the successful use of CRISPR-edited stem cells for treating blood disorders like sickle cell...
3.
Kesavan G, Machate A, Brand M
Zebrafish
. 2021 Sep;
18(6):369-373.
PMID: 34495758
Genetically encoded fluorescent tags such as green fluorescent protein fused to protein have revolutionized cell biology as they permit high-resolution protein imaging in live systems. Split fluorescent proteins, with a...
4.
Hans S, Zoller D, Hammer J, Stucke J, Spiess S, Kesavan G, et al.
Nat Commun
. 2021 Feb;
12(1):1125.
PMID: 33602923
Conditional gene inactivation is a powerful tool to determine gene function when constitutive mutations result in detrimental effects. The most commonly used technique to achieve conditional gene inactivation employs the...
5.
Tsata V, Mollmert S, Schweitzer C, Kolb J, Mockel C, Bohm B, et al.
Dev Cell
. 2021 Jan;
56(4):509-524.e9.
PMID: 33412105
In mammals, perivascular cell-derived scarring after spinal cord injury impedes axonal regrowth. In contrast, the extracellular matrix (ECM) in the spinal lesion site of zebrafish is permissive and required for...
6.
Kesavan G, Raible F, Gupta M, Machate A, Yilmaz D, Brand M
Cell Tissue Res
. 2020 Dec;
383(3):987-1002.
PMID: 33367974
Extracellular signals play essential roles during embryonic patterning by providing positional information in a concentration-dependent manner, and many such signals, like Wnt, fibroblast growth factor (FGF), Hedgehog (Hh), and retinoic...
7.
Gillotay P, Shankar M, Haerlingen B, Sema Elif E, Pozo-Morales M, Garteizgogeascoa I, et al.
EMBO Rep
. 2020 Nov;
21(12):e50612.
PMID: 33140917
The thyroid gland regulates growth and metabolism via production of thyroid hormone in follicles composed of thyrocytes. So far, thyrocytes have been assumed to be a homogenous population. To uncover...
8.
Kesavan G, Machate A, Hans S, Brand M
Development
. 2020 May;
147(11).
PMID: 32439756
The formation and maintenance of sharp boundaries between groups of cells play a vital role during embryonic development as they serve to compartmentalize cells with similar fates. Some of these...
9.
Kesavan G, Hammer J, Hans S, Brand M
Cell Tissue Res
. 2018 Feb;
372(1):41-50.
PMID: 29435650
New genome-editing approaches, such as the CRISPR/Cas system, have opened up great opportunities to insert or delete genes at targeted loci and have revolutionized genetics in model organisms like the...
10.
Kesavan G, Chekuru A, Machate A, Brand M
Front Neuroanat
. 2017 Jul;
11:52.
PMID: 28713249
The midbrain-hindbrain boundary (MHB) acts as an organizer and controls the fate of neighboring cells to develop into either mesencephalic (midbrain) or metencephalic (hindbrain) cells by secreting signaling molecules like...